Publication detail

The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease

ROY, S. GUMULEC, J. KUMAR, A. RAUDENSKÁ, M. BAIG, M. POLANSKÁ, H. BALVAN, J. GUPTA, M. BABULA, P. ODSTRČILÍK, J. CHOI, I. PROVAZNÍK, I. MASAŘÍK, M.

Original Title

The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease

Type

journal article in Web of Science

Language

English

Original Abstract

Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.

Keywords

Alzheimer’s Disease, Flow Cytometry, Immunodetection, Metallothionein-3, Molecular Dynamics, qRT-PCR

Authors

ROY, S.; GUMULEC, J.; KUMAR, A.; RAUDENSKÁ, M.; BAIG, M.; POLANSKÁ, H.; BALVAN, J.; GUPTA, M.; BABULA, P.; ODSTRČILÍK, J.; CHOI, I.; PROVAZNÍK, I.; MASAŘÍK, M.

Released

15. 8. 2017

Publisher

Wiley Periodicals

Location

New York, USA

ISBN

2162-3279

Periodical

Brain and Behavior

Year of study

7

Number

9

State

United States of America

Pages from

1

Pages to

9

Pages count

9

URL

http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract

Full text in the Digital Library

http://hdl.handle.net/11012/69945

BibTex

@article{BUT139120,
  author="Sudeep {Roy} and Jaromír {Gumulec} and Akhil {Kumar} and Martina {Raudenská} and Mohd Hassan {Baig} and Hana {Polanská} and Jan {Balvan} and Mansi {Gupta} and Petr {Babula} and Jan {Odstrčilík} and Inho {Choi} and Valentine {Provazník} and Michal {Masařík}",
  title="The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease",
  journal="Brain and Behavior",
  year="2017",
  volume="7",
  number="9",
  pages="1--9",
  doi="10.1002/brb3.799",
  issn="2162-3279",
  url="http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract"
}