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JARÁBKOVÁ, S. KÁBRTOVÁ, P. MRAVEC, F. PEKAŘ, M.
Original Title
Advanced Microrheological Techniques In The Research Of Hydrogels
Type
abstract
Language
English
Original Abstract
This work is focused on the use of advanced fluorescence correlation spectroscopy technique (FCS) in microrheological characterization of hydrogels. Hydrogels were prepared from negatively charged polymer (sodium hyaluronate) and oppositely charged surfactant (cetyltrimethylammonium bromide) in physiological environment. Low, medium and high molecular weight sodium hyaluronate was used. Our hydrogels contain more than 90 % of water and they are able to solubilize hydrophobic and hydrophilic species. These hydrogels contain hydrophobic nanodomains (nanocontainers) and can be promising materials for the use in many applications, e.g. in topical applications or local drug delivery systems. Main aim of this work is to study microrhelological behavior of these systems and usability of FCS technique in these systems. For microrheological FCS analysis were used fluorescently labelled particles. Optimum particle size was selected based on analysis of Newtonian glycerol solutions. The results of FCS hydrogel microrheology were compared with the measurement of hyaluronan solutions. Concentration and molecular weight of this biopolymer were monitored.
Keywords
hydrogels, fluorescence correlation spectroscopy (FCS), nanocontainers, surfactants
Authors
JARÁBKOVÁ, S.; KÁBRTOVÁ, P.; MRAVEC, F.; PEKAŘ, M.
Released
10. 9. 2017
Publisher
Johan Hofkens, Maarten Roeffaers & Kris Janssen
Location
Bruggy, Belgie
Pages from
211
Pages to
Pages count
1
BibTex
@misc{BUT139921, author="Sabína {Jarábková} and Petra {Kábrtová} and Filip {Mravec} and Miloslav {Pekař}", title="Advanced Microrheological Techniques In The Research Of Hydrogels", booktitle="Abstract book", year="2017", series="1", edition="1", pages="211--211", publisher="Johan Hofkens, Maarten Roeffaers & Kris Janssen", address="Bruggy, Belgie", note="abstract" }