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JANOUŠEK, O. STRAČINA, T. RONZHINA, M. HEJČ, J. STARK, T. RUDA, J. MICALE, V. KOLÁŘOVÁ, J. NOVÁKOVÁ, M. PROVAZNÍK, I.
Original Title
The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats
Type
conference paper
Language
English
Original Abstract
Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.
Keywords
Heart Rate Variability; Haloperidol
Authors
JANOUŠEK, O.; STRAČINA, T.; RONZHINA, M.; HEJČ, J.; STARK, T.; RUDA, J.; MICALE, V.; KOLÁŘOVÁ, J.; NOVÁKOVÁ, M.; PROVAZNÍK, I.
Released
30. 9. 2017
Publisher
Computing in Cardiology 2017
Location
Rennes, France
ISBN
978-1-5090-0684-7
Book
Computing in Cardiology, 2017
Edition
44
Edition number
1
0276-6574
Periodical
Computers in Cardiology
State
United States of America
Pages from
Pages to
4
Pages count
BibTex
@inproceedings{BUT141020, author="Oto {Janoušek} and Tibor {Stračina} and Marina {Filipenská} and Jakub {Hejč} and Tibor {Stark} and Jana {Ruda} and Vincenzo {Micale} and Jana {Kolářová} and Marie {Nováková} and Valentine {Provazník}", title="The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats", booktitle="Computing in Cardiology, 2017", year="2017", series="44", journal="Computers in Cardiology", number="1", pages="1--4", publisher="Computing in Cardiology 2017", address="Rennes, France", doi="10.22489/CinC.2017.150-161", isbn="978-1-5090-0684-7", issn="0276-6574" }