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Lenka Musilová, Aleš Mráček, Adriana Kovalcik, Petr Smolka, Antonín Minařík, Petr Humpolíček, Robert Vícha, Petr Ponížil
Original Title
Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility
Type
journal article in Web of Science
Language
English
Original Abstract
Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.
Keywords
Hyaluronan Lignin Hydrogel Swelling behaviour Mechanical properties Biocompatibility of hydrogels
Authors
Released
1. 1. 2018
Publisher
Elsevier
Location
Amsterdam
ISBN
1879-1344
Periodical
Carbohydrate Polymers (electronic)
Year of study
181
Number
1
State
United Kingdom of Great Britain and Northern Ireland
Pages from
394
Pages to
403
Pages count
10
URL
http://www.sciencedirect.com/science/article/pii/S0144861717311918
BibTex
@article{BUT141040, author="Adriána {Kovalčík}", title="Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility", journal="Carbohydrate Polymers (electronic)", year="2018", volume="181", number="1", pages="394--403", doi="10.1016/j.carbpol.2017.10.048", issn="1879-1344", url="http://www.sciencedirect.com/science/article/pii/S0144861717311918" }