Publication detail

Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin

MOULICK, A. MILOSAVLJEVIĆ, V. NGUYEN, H. KOPEL, P. ADAM, V.

Original Title

Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin

Type

journal article in Web of Science

Language

English

Original Abstract

It has been suggested that multiwalled carbon nanotubes (MWCNTs) interacting with pharmaceutics may be introduced into the body as nanocarriers. To deliver the anticancer drugs, covalent or noncovalent functionalization of MWCNTs is required. In this study, the influence of oxidation on MWCNTs in the interaction with chemotherapeutic drug, doxorubicin, was characterized. The binding of doxorubicin with MWCNTs decreased rapidly with the increasing oxidation period with sulfuric acid. However, with nitric acid, the interaction increased initially and slowly decreased with time. The best results were obtained for sulfuric and nitric acid following 1 and 3h of oxidation, respectively. The results show that sulfuric acid provided more favorable interaction for MWCNTs with doxorubicin than nitric acid.

Keywords

Carbon nanotubes (CNTs); differential pulse voltammetry (DPV); glassy carbon electrode (GCE); multiwalled carbon nanotubes (MWCNTs); single-walled carbon nanotubes (SWCNTs)

Authors

MOULICK, A.; MILOSAVLJEVIĆ, V.; NGUYEN, H.; KOPEL, P.; ADAM, V.

Released

1. 11. 2017

ISBN

0003-2719

Periodical

ANALYTICAL LETTERS

Year of study

50

Number

14

State

United States of America

Pages from

2335

Pages to

2341

Pages count

7

BibTex

@article{BUT141269,
  author="Amitava {Moulick} and Vedran {Milosavljević} and Hoai Viet {Nguyen} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin",
  journal="ANALYTICAL LETTERS",
  year="2017",
  volume="50",
  number="14",
  pages="2335--2341",
  doi="10.1080/00032719.2017.1284860",
  issn="0003-2719"
}