Publication detail

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

RAUDENSKÁ, M. GUMULEC, J. BABULA, P. STRAČINA, T. SZTALMACHOVÁ, M. POLANSKÁ, H. ADAM, V. KIZEK, R. NOVÁKOVÁ, M. MASAŘÍK, M.

Original Title

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

Type

journal article in Web of Science

Language

English

Original Abstract

Haloperidol (HP) is used for the symptomatic treatment of psychosis, manic phases, hyperactivity, aggressiveness, and acute delirium. Long-term use leads to various adverse side effects, especially to severe impairment of extrapyramidal nerve tracts and in particular, altered QT interval and increased incidence of arrhytmias. It is believed that cytotoxicity of HP and its metabolites is responsible for both neurotoxicity and cardiotoxicity. Extrapyramidal and cardiac adverse side effects may be explained by the HP-induced oxidative stress, as implicated by many studies. HP was reported to induce lipid peroxidation with subsequent membrane changes, responsible for cell death. Vice versa, cells resistant to oxidative stress are also resistant to the toxic effects of HP. Similarly, high percentage of patients suffering from extrapyramidal symptoms treated by vitamin E and other lipid-soluble antioxidants demonstrates diminishing of these adverse side effects. HP's ability to induce oxidative stress by multi-modal action (increased metabolism of dopamine, decrease of glutathione content, induction of NF-kappa B transcription factor, and inhibition of complex I of respiratory chain) has been established just recently. This review brings summarizing view on the cytotoxicity of haloperidol and involvement of reactive oxygen species and oxidative stress HP-induced cytotoxicity.

Keywords

Arrhytmia; cardiotoxicity; dopamine; haloperidol; oxidative stress; Torsade de Pointes

Authors

RAUDENSKÁ, M.; GUMULEC, J.; BABULA, P.; STRAČINA, T.; SZTALMACHOVÁ, M.; POLANSKÁ, H.; ADAM, V.; KIZEK, R.; NOVÁKOVÁ, M.; MASAŘÍK, M.

Released

1. 12. 2013

ISBN

1389-5575

Periodical

MINI-REVIEWS IN MEDICINAL CHEMISTRY

Year of study

13

Number

14

State

United Arab Emirates

Pages from

1993

Pages to

1998

Pages count

6

BibTex

@article{BUT142306,
  author="Martina {Raudenská} and Jaromír {Gumulec} and Petr {Babula} and Tibor {Stračina} and Markéta {Sztalmachová} and Hana {Polanská} and Vojtěch {Adam} and René {Kizek} and Marie {Nováková} and Michal {Masařík}",
  title="Haloperidol Cytotoxicity and Its Relation to Oxidative Stress",
  journal="MINI-REVIEWS IN MEDICINAL CHEMISTRY",
  year="2013",
  volume="13",
  number="14",
  pages="1993--1998",
  issn="1389-5575"
}