Publication detail

EFFECT OF MELITTIN ON INFLUENZA-INFECTED CHICKEN EMBRYOS

MICHÁLEK, P. ZÍTKA, O. KREJČOVÁ, L. PŘIDAL, A. KOMÍNKOVÁ, M. GURÁŇ, R. MILOSAVLJEVIĆ, V. KOPEL, P. HEGER, Z. ADAM, V. KIZEK, R.

Original Title

EFFECT OF MELITTIN ON INFLUENZA-INFECTED CHICKEN EMBRYOS

Type

conference paper

Language

English

Original Abstract

Antimicrobial peptides are peptides isolated from a wide range of organisms that exert microbicidal activity against a wide spectrum of targets, including bacteria, viruses, fungi, and parasites. These peptides are aimed directly on the phospholipid bilayer and do not target on the cellular or metabolic activities of the cells as antibiotics and other drugs do. But thanks to many vital proteins associated with the membrane, these peptides can also influence these structures and therefore facilitate and accelerate their death. Melittin is a well-characterized pore-forming lytic amphiphilic peptide (consisting of 26 amino acids) found in bee venom. The amphiphilic property of this peptide makes it water-soluble and yet it spontaneously associates with natural and artificial membranes. This integration leads to the distortion and permeabilization of the membrane. In this study melittin has been utilized to study antiviral properties against influenza A virus. Melittin was used in the mixture with the influenza A virus and together were inoculated into chicken embryo. Living conditions were monitored during infection. After death of chicken, biochemistry of allantoic fluid was performed.

Keywords

Melittin; Influenza virus; Chicken embryos

Authors

MICHÁLEK, P.; ZÍTKA, O.; KREJČOVÁ, L.; PŘIDAL, A.; KOMÍNKOVÁ, M.; GURÁŇ, R.; MILOSAVLJEVIĆ, V.; KOPEL, P.; HEGER, Z.; ADAM, V.; KIZEK, R.

Released

12. 11. 2015

ISBN

978-80-7509-363-9

Book

MENDELNET 2015

Pages from

475

Pages to

479

Pages count

5

BibTex

@inproceedings{BUT142601,
  author="Petr {Michálek} and Ondřej {Zítka} and Ludmila {Krejčová} and Antonín {Přidal} and Markéta {Komínková} and Roman {Guráň} and Vedran {Milosavljević} and Pavel {Kopel} and Zbyněk {Heger} and Vojtěch {Adam} and René {Kizek}",
  title="EFFECT OF MELITTIN ON INFLUENZA-INFECTED CHICKEN EMBRYOS",
  booktitle="MENDELNET 2015",
  year="2015",
  pages="475--479",
  isbn="978-80-7509-363-9"
}