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JIŘÍK, R. TAXT, T. SOUČEK, K. KRATOCHVÍLA, J. MACÍČEK, O. DRAŽANOVÁ, E. STARČUK, Z.
Original Title
Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI
Type
conference paper
Language
English
Original Abstract
In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability-surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.
Keywords
DCE-MRI, perfusion, blind deconvolution
Authors
JIŘÍK, R.; TAXT, T.; SOUČEK, K.; KRATOCHVÍLA, J.; MACÍČEK, O.; DRAŽANOVÁ, E.; STARČUK, Z.
Released
1. 1. 2016
ISBN
1352-8661
Periodical
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Year of study
29
Number
S1
State
United States of America
Pages from
447
Pages to
448
Pages count
2
BibTex
@inproceedings{BUT142781, author="JIŘÍK, R. and TAXT, T. and SOUČEK, K. and KRATOCHVÍLA, J. and MACÍČEK, O. and DRAŽANOVÁ, E. and STARČUK, Z.", title="Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI", booktitle="MAGMA", year="2016", journal="MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE", volume="29", number="S1", pages="447--448", doi="10.1007/s10334-016-0571-2", issn="1352-8661" }