Publication detail

Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?

HEGER, Z. MERLOS RODRIGO, M. KŘÍŽKOVÁ, S. RUTTKAY-NEDECKÝ, B. ZALEWSKA, M. PLANELLS DEL POZO, E. PELFRENE, A. POURRUT, B. STIBOROVÁ, M. ECKSCHLAGER, T. EMRI, G. KIZEK, R. ADAM, V.

Original Title

Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?

Type

journal article in Web of Science

Language

English

Original Abstract

Cardiotoxicity is a serious complication of anticancer therapy by anthracycline antibiotics. Except for intercalation into DNA/RNA structure, inhibition of DNA-topoisomerase and histone eviction from chromatin, the main mechanism of their action is iron-mediated formation of various forms of free radicals, which leads to irreversible damage to cancer cells. The most serious adverse effect of anthracyclines is, thus, cardiomyopathy leading to congestive heart failure, which is caused by the same mechanisms. Here, we briefly summarize the basic types of free radicals formed by anthracyclines and the main processes how to scavenge them. From these, the main attention is paid to metallothioneins. These low-molecular cysteine-rich proteins are introduced and their functions and properties are reviewed. Further, their role in detoxification of metals and drugs is discussed. Based on these beneficial roles, their use as a new therapeutic agent against oxidative stress and for cardioprotection is critically evaluated with respect to their ability to increase chemoresistance against some types of commonly used cytostatics.

Keywords

Anthracyclines; cardioprotection; cellular oxidative stress; chemoresistance; doxorubicin; free radicals; metal-lothionein

Authors

HEGER, Z.; MERLOS RODRIGO, M.; KŘÍŽKOVÁ, S.; RUTTKAY-NEDECKÝ, B.; ZALEWSKA, M.; PLANELLS DEL POZO, E.; PELFRENE, A.; POURRUT, B.; STIBOROVÁ, M.; ECKSCHLAGER, T.; EMRI, G.; KIZEK, R.; ADAM, V.

Released

1. 1. 2016

ISBN

1389-4501

Periodical

CURRENT DRUG TARGETS

Year of study

17

Number

12

State

United Arab Emirates

Pages from

1438

Pages to

1451

Pages count

14

BibTex

@article{BUT143010,
  author="Zbyněk {Heger} and Miguel Ángel {Merlos Rodrigo} and Soňa {Křížková} and Branislav {Ruttkay-Nedecký} and Marta Barbara {Zalewska} and Ellena {Planells del Pozo} and Aurelie {Pelfrene} and Bertrand {Pourrut} and Marie {Stiborová} and Tomáš {Eckschlager} and Gabriela {Emri} and René {Kizek} and Vojtěch {Adam}",
  title="Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?",
  journal="CURRENT DRUG TARGETS",
  year="2016",
  volume="17",
  number="12",
  pages="1438--1451",
  doi="10.2174/1389450116666151001113304",
  issn="1389-4501"
}