Publication detail

Experimental methods for flow and aerosol measurements in human airways and their replicas

LÍZAL, F. JEDELSKÝ, J. MORGAN, K. BAUER, K. LLOP, J. COSSIO, U. KASSINOS, S. VERBANCK, S. RUIZ-CABELLO, J. SANTOS, A. KOCH, E. SCHNABEL, C.

Original Title

Experimental methods for flow and aerosol measurements in human airways and their replicas

Type

journal article in Web of Science

Language

English

Original Abstract

Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.

Keywords

Computational fluid particle dynamics;Human airways;Lungs;Experimental methods;Medical imaging;Aerosol deposition;Velocimetry techniques;Flow measurement techniques;Gas–liquid two-phase flow;CFD validation

Authors

LÍZAL, F.; JEDELSKÝ, J.; MORGAN, K.; BAUER, K.; LLOP, J.; COSSIO, U.; KASSINOS, S.; VERBANCK, S.; RUIZ-CABELLO, J.; SANTOS, A.; KOCH, E.; SCHNABEL, C.

Released

15. 2. 2018

Publisher

Elsevier

Location

Amsterdam, Nizozemsko

ISBN

0928-0987

Periodical

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Year of study

113

Number

SI

State

Kingdom of the Netherlands

Pages from

95

Pages to

131

Pages count

37

URL

https://www.sciencedirect.com/science/article/pii/S0928098717304657

Full text in the Digital Library

http://hdl.handle.net/11012/203515

BibTex

@article{BUT143632,
  author="František {Lízal} and Jan {Jedelský} and Kaye {Morgan} and Katrin {Bauer} and Jordi {Llop} and Unai {Cossio} and Stavros {Kassinos} and Sylvia {Verbanck} and Jesús {Ruiz-Cabello} and Arnoldo {Santos} and Edmund {Koch} and Christian {Schnabel}",
  title="Experimental methods for flow and aerosol measurements in human airways and their replicas",
  journal="EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES",
  year="2018",
  volume="113",
  number="SI",
  pages="95--131",
  doi="10.1016/j.ejps.2017.08.021",
  issn="0928-0987",
  url="https://www.sciencedirect.com/science/article/pii/S0928098717304657"
}