Publication detail

COMPARISON OF FOUR METHODS FOR DETERMINATION OF DOXORUBICIN

NGUYEN, H. RUTTKAY-NEDECKÝ, B. DOSTÁLOVÁ, S. KOMÍNKOVÁ, M. JAROŠOVÁ, A. DOČEKALOVÁ, M. STIBOROVÁ, M. ECKSCHLAGER, T. ADAM, V. KIZEK, R.

Original Title

COMPARISON OF FOUR METHODS FOR DETERMINATION OF DOXORUBICIN

Type

conference paper

Language

English

Original Abstract

Doxorubicin hydrochloride, is a cytotoxic anthracycline antibiotic isolated from cultures of fungus Streptomyces peucetius var. caesius. The most common use of doxorubicin in cancer therapy is for the treatment of various types of testicular cancer, leukemia, nonHodgkin’s and Hodgkin’s lymphoma, osteosarcoma, neuroblastoma, and breast carcinoma [1]. Several methods have previously been reported for quantification of doxorubicin in biological fluids and tissues. Techniques such as voltammetry for urine [2, 3], high performance liquid chromatography (HPLC) for rat plasma and tissues [4], human plasma of cancer patients [5] were used. In this work a suitability of four different methods utilized for doxorubicin determination was compared.

Keywords

Doxorubicin; cancer therapy; high performance liquid chromatography; differential pulse voltammetry; spectrophotometry; fluorimetry

Authors

NGUYEN, H.; RUTTKAY-NEDECKÝ, B.; DOSTÁLOVÁ, S.; KOMÍNKOVÁ, M.; JAROŠOVÁ, A.; DOČEKALOVÁ, M.; STIBOROVÁ, M.; ECKSCHLAGER, T.; ADAM, V.; KIZEK, R.

Released

23. 9. 2015

ISBN

978-80-904959-3-7

Book

CECE 2015

Pages from

160

Pages to

163

Pages count

4

BibTex

@inproceedings{BUT145490,
  author="Hoai Viet {Nguyen} and Branislav {Ruttkay-Nedecký} and Simona {Dostálová} and Markéta {Komínková} and Adéla {Jarošová} and Michaela {Dočekalová} and Marie {Stiborová} and Tomáš {Eckschlager} and Vojtěch {Adam} and René {Kizek}",
  title="COMPARISON OF FOUR METHODS FOR DETERMINATION OF DOXORUBICIN",
  booktitle="CECE 2015",
  year="2015",
  pages="160--163",
  isbn="978-80-904959-3-7"
}