Přístupnostní navigace
E-application
Search Search Close
Publication detail
STANISAVLJEVIC, M. VACULOVIČOVÁ, M. KOPEL, P. ADAM, V. ECKSCHLAGER, T. KIZEK, R.
Original Title
ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION
Type
conference paper
Language
English
Original Abstract
Doxorubicin is an effective cytostatic drug used for treatment of some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma and/or multiple myeloma. Even though this drug is effective for cancer treatment its toxicity, mainly cardiotoxicity, is limiting the use. For this reason, encapsulation of the drug into the biocarriers, lowering the toxicity, is widely investigated. One of such carriers may be a protein called apoferritin, which is due to the cavity in its structure, able to incept the molecule of interest. Subsequent decrease of pH leads to the opening of the structure and release of the content. The aim of this study is to investigate the behavior of the encapsulated doxorubicin using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).
Keywords
doxorubicin; apoferritin; capillary electrophoresis; cancer; cytostatic drug
Authors
STANISAVLJEVIC, M.; VACULOVIČOVÁ, M.; KOPEL, P.; ADAM, V.; ECKSCHLAGER, T.; KIZEK, R.
Released
2. 11. 2012
ISBN
978-80-904959-1-3
Book
CECE 2012
Pages from
209
Pages to
212
Pages count
4
BibTex
@inproceedings{BUT145848, author="Maja {Stanisavljevic} and Markéta {Vaculovičová} and Pavel {Kopel} and Vojtěch {Adam} and Tomáš {Eckschlager} and René {Kizek}", title="ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION", booktitle="CECE 2012", year="2012", pages="209--212", isbn="978-80-904959-1-3" }