Publication detail

High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures

MONTUFAR JIMENEZ, E. CASAS LUNA, M. HORYNOVÁ, M. TKACHENKO, S. FOHLEROVÁ, Z. DÍAZ DE LA TORRE, S. DVOŘÁK, K. ČELKO, L. KAISER, J.

Original Title

High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures

Type

journal article in Web of Science

Language

English

Original Abstract

In this work alpha tricalcium phosphate (a-TCP)/iron (Fe) composites were developed as a new family of biodegradable, load-bearing and cytocompatible materials. The composites with composition from pure ceramic to pure metallic samples were consolidated by pulsed electric current assisted sintering to minimise processing time and temperature while improving their mechanical performance. The mechanical strength of the composites was increased and controlled with the Fe content, passing from brittle to ductile failure. In particular, the addition of 25 vol% of Fe produced a ceramic matrix composite with elastic modulus much closer to cortical bone than that of titanium or biodegradable magnesium alloys and specific compressive strength above that of stainless steel, chromium-cobalt alloys and pure titanium, currently used in clinic for internal fracture fixation. All the composites studied exhibited higher degradation rate than their individual components, presenting values around 200 lm/year, but also their compressive strength did not show a significant reduction in the period required for bone fracture consolidation. Composites showed preferential degradation of a-TCP areas rather than b-TCP areas, suggesting that a-TCP can produce composites with higher degradation rate. The composites were cytocompatible both in indirect and direct contact with bone cells. Osteoblast-like cells attached and spread on the surface of the composites, presenting proliferation rate similar to cells on tissue culture-grade polystyrene and they showed alkaline phosphatase activity. Therefore, this new family of composites is a potential alternative to produce implants for temporal reduction of bone fractures.

Keywords

Biodegradable metal; Tricalcium phosphate; Spark plasma sintering; Mechanical properties; Degradation test

Authors

MONTUFAR JIMENEZ, E.; CASAS LUNA, M.; HORYNOVÁ, M.; TKACHENKO, S.; FOHLEROVÁ, Z.; DÍAZ DE LA TORRE, S.; DVOŘÁK, K.; ČELKO, L.; KAISER, J.

Released

9. 2. 2018

Publisher

Elsevier

Location

United Kingdom of Great Britain and Northern Ireland

ISBN

1742-7061

Periodical

Acta Biomaterialia

Number

70

State

United Kingdom of Great Britain and Northern Ireland

Pages from

293

Pages to

303

Pages count

11

URL

https://www.sciencedirect.com/science/article/pii/S1742706118300722

Full text in the Digital Library

http://hdl.handle.net/11012/244135

BibTex

@article{BUT147198,
  author="Edgar Benjamin {Montufar Jimenez} and Mariano {Casas Luna} and Miroslava {Horynová} and Serhii {Tkachenko} and Zdenka {Fohlerová} and Sebastian {Díaz de la Torre} and Karel {Dvořák} and Ladislav {Čelko} and Jozef {Kaiser}",
  title="High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures",
  journal="Acta Biomaterialia",
  year="2018",
  number="70",
  pages="293--303",
  doi="10.1016/j.actbio.2018.02.002",
  issn="1742-7061",
  url="https://www.sciencedirect.com/science/article/pii/S1742706118300722"
}