Publication detail

Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment

TESAŘOVÁ, B. DOSTÁLOVÁ, S. HYNEK, D. ADAM, V. HEGER, Z.

Original Title

Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment

Type

conference paper

Language

English

Original Abstract

Many researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To overcome their failure in in vivo use, the effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin were tested in this work. Various properties of these modified apoferitin nanoparticles were studied, such as their size or degree of hemolysis. TEM characterization was also performed. The formation of hard coronas on these particles in plasma environment was evaluated using SDS-PAGE electrophoresis. The best biocompatibility results were obtained using apoferritin nanoparticles with PEG surface modification.

Keywords

Apoferritin; nanomedicine; protein coronas; surface modifications

Authors

TESAŘOVÁ, B.; DOSTÁLOVÁ, S.; HYNEK, D.; ADAM, V.; HEGER, Z.

Released

31. 12. 2017

Publisher

Mendel University in Brno

ISBN

978-80-7509-529-9

Book

MendelNet 2017

Pages from

937

Pages to

942

Pages count

6

URL

https://mendelnet.cz/artkey/mnt-201701-0110_Surface-PEGylation-and-PASylation-to-regulate-nanoparticle-interactions-with-biological-environment.php?back=/magno/mnt/2017/mn1.php?secid=4

Full text in the Digital Library

http://hdl.handle.net/11012/84183

BibTex

@inproceedings{BUT148770,
  author="Barbora {Tesařová} and Simona {Dostálová} and David {Hynek} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment",
  booktitle="MendelNet 2017",
  year="2017",
  pages="937--942",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-529-9",
  url="https://mendelnet.cz/artkey/mnt-201701-0110_Surface-PEGylation-and-PASylation-to-regulate-nanoparticle-interactions-with-biological-environment.php?back=/magno/mnt/2017/mn1.php?secid=4"
}