Transport of organic dyes in bioplymeric hydrogels

abstract

English

Biopolymeric hydrogels based on oppositely charged polyelectrolytes and surfactants can contain micelle-like nanostructures potentially usable for medical applications. Integration of the nanocontainers for pharmaceutically active substances into hydrogel matrix can solve problems with their hydrophobic nature. Interactions of biopolymeric electrolytes with oppositely charged surfactants which can result in dissolving hydrophobes in micelle-like nanocontainers formed by surfactants. In this study, hydrogels were prepared either from hyaluronan and cationic surfactant septonex (carbethoxypendecinium bromide) or from diethylaminoethyl dextrane and sodium dodecylsulphate as described previously. Nile red was used as a model diffusion probe in order to investigate the release of active substances from hydrogel. The probe was incorporated into hydrogel structures in their preparations and its release was monitored in time by UV/VIS spectrometry. It was found that the equilibrium between the formed hydrogel and supernatant can be established after several days or weeks. A re-arrangement of diffusion probe in the hydrogel structure was connected with the decrease in concentration of supernatant. Therefore, some molecules of dye were incorporated into the hydrogel after its preparation. If the supernatant was replaces by pure solution without dye, a new equilibrium was established and the diffusion of dye from the hydrogel was observed. Diffusivity of dye in hydrogels was determined on the basis of mathematical model described our previous work.

diffusion; dye; hydrogel; hyaluronan; dextran; surfactant

KLUČÁKOVÁ, M.; JARÁBKOVÁ, S.; VELCER, T.; PEKAŘ, M.

3. 9. 2018

Ljubljana

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