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SLANINOVÁ, E. SEDLÁČEK, P. OBRUČA, S.
Original Title
Polyhadroxyalkanoates –microbial polyesters with a complex protective effect against diverse stress factors
Type
abstract
Language
English
Original Abstract
Polyhydroxyalkanoates (PHAs) are hydrophobic polyesters produced and accumulated by numerous microorganisms in a form of intracellular granules filled with the polymer and covered by a layer of proteins. The polymer content of bacteria can reach up to 90 % of the weight of cellular dry matter. In our recent work, we have confirmed experimentally that PHAs granules do not serve only as a source of carbon or energy but also as a cell component with a complex protective performance. PHAs accumulating bacteria cells are synthesizing and degrading the polymers simultaneously. We have confirmed that the monomer of PHAs, which is found in the polymer-accumulating bacterial in a substantial amount, serves as a chemical chaperone and a cryo- protective solute. Furthermore, we have revealed that the protective function of the polymer against various stressors such as non-optimal pH, high and low temperature, osmotic up- and down-shock, UV exposure etc. is conditioned by the native amorphous state of PHAs. This liquid-like state of PHAs, found only in-vivo, is involved in the adaptation of cells supporting them to survive sudden changes of the environment.
Keywords
PHA, stress factors, protectants, intracellular granule
Authors
SLANINOVÁ, E.; SEDLÁČEK, P.; OBRUČA, S.
Released
13. 11. 2018
Publisher
Tiskárna Didot, spol. s. r. o.
Location
Trnkova 119, 628 00 Brno-Líšeň
ISBN
978-80-210-9069-9
Book
XIX. setkání biochemiků a molekulárních biologů
Pages from
44
Pages to
Pages count
103
BibTex
@misc{BUT151441, author="Eva {Slaninová} and Petr {Sedláček} and Stanislav {Obruča}", title="Polyhadroxyalkanoates –microbial polyesters with a complex protective effect against diverse stress factors", booktitle="XIX. setkání biochemiků a molekulárních biologů", year="2018", pages="44--44", publisher="Tiskárna Didot, spol. s. r. o.", address="Trnkova 119, 628 00 Brno-Líšeň", isbn="978-80-210-9069-9", note="abstract" }