High-resolution ultrasonic spectroscopy for studying of polyelectrolytes and surfactants

abstract

English

Hyaluronan is a well-known biopolymer synthesized in various organisms including the human body. It is formed by a repeated basic dimeric unit composed of glucuronic acid and N-acetyl-glucosamine. Due to its biological origin, biocompatibility, non-immunogenicity, and biodegradability, hyaluronan has found various applications in the fields of cosmetics and medicine. Due to the presence of carboxylic groups in its backbone, hyaluronan behaves in aqueous environments as a polyelectrolyte. At physiological pH values, hyaluronan possesses negative charge and is thus capable of attractive electrostatic interactions with positively charged partners. Thus, interactions between hyaluronan and cationic surfactants have been intensively studied as a specific example of a broader class of polyelectrolyte-surfactant interactions. The binding of surfactant to hyaluronan was detected for surfactants with an alkyl chain consisting of at least ten carbon atoms (1, 2). Interactions between hyaluronan and the cationic surfactant Septonex were studied using high resolution ultrasound spectroscopy. Four different interaction regions were identified in aqueous solution in a narrow interval of surfactant concentrations. In contrast, in 0.15 mol/L NaCl solution, essentially only two principal regions were observed. Hyaluronan-Septonex aggregates were generally less compressible than Septonex monomers or micelles and their formation in water was not appreciably affected by hyaluronan molecular weight.

Polyelectrolytes, surfactants, high resolution ultrasonic spectroscopy

KARGEROVÁ, A.; PEKAŘ, M.

5. 10. 2018

Brno University of Technology, Faculty of Chemistry

Brno

12

12

32

http://www.hrus2018.com//