Publication detail

Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

KHEZRI, B. MOHSEN BELADI, M. KREJČOVÁ, L. HEGER, Z. SOFER, Z. PUMERA, M.

Original Title

Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

Type

journal article in Web of Science

Language

English

Original Abstract

Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self-propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high-speed tubular electrically conductive micromachine based on reduced nanographene oxide (n-rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n-rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single- or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n-rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n-rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon-based drug carriers with a fast and efficient electrochemical drug-release mechanism.

Keywords

doxorubicin; drug delivery; electrochemical release; micromotors; reduced graphene oxide

Authors

KHEZRI, B.; MOHSEN BELADI, M.; KREJČOVÁ, L.; HEGER, Z.; SOFER, Z.; PUMERA, M.

Released

24. 1. 2019

ISBN

1616-301X

Periodical

ADVANCED FUNCTIONAL MATERIALS

Year of study

29

Number

4

State

Federal Republic of Germany

Pages from

1

Pages to

10

Pages count

10

URL

https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806696

BibTex

@article{BUT156116,
  author="Bahareh {Khezri} and Mousavi {Mohsen Beladi} and Ludmila {Krejčová} and Zbyněk {Heger} and Zdeněk {Sofer} and Martin {Pumera}",
  title="Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines",
  journal="ADVANCED FUNCTIONAL MATERIALS",
  year="2019",
  volume="29",
  number="4",
  pages="1--10",
  doi="10.1002/adfm.201806696",
  issn="1616-301X",
  url="https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806696"
}