Publication detail

High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

RAHBAR, M. NESTERENKO, P. PAULL, B. MACKA, M.

Original Title

High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Type

journal article in Web of Science

Language

English

Original Abstract

The deposition of chemical reagent inks on paper is a crucial step in the development and fabrication of microfluidic paper-based analytical devices (mu PADs). A pen-plotting approach, delivering chemical ink deposition using technical pens filled with reagents and inserted into a desktop electronic plotter, is shown herein to be a versatile, low-cost, simple, rapid, reproducible, and high-throughput solution. The volume of the deposited ink was quantified gravimetrically, confirming that nanoliter volumes of reagents can be deposited reproducibly (e.g. 7.55 +/- 0.37 nL/mm for a plotting speed of 10 cm/s) in detection zones of mu PADs, typically spatially defined using wax printing. This approach was further investigated with regard to deposition of reagents in different geometrical forms (circular and linear), so demonstrating its applicability for preparation of mu PADs with flexible design and application. By adjusting the plotting speed for linear deposition, lines with a relatively large range of widths (approximate to 628-1192 mm) were created. Circular deposition was also demonstrated via delivery of reagents within wax printed circular fluidic barriers of a range of diameters (inner diameter = 1.5-7 mm). These capabilities were practically demonstrated via the fabrication of mu PADs, based upon differing detection principles for determination of aluminum in natural waters using Morin as the fluorescent reagent. Traditional mu PADs based on digital image colorimetry (DIC) were produced using circular deposition, whilst distance-based mu PADs exploited linear deposition. Both types of mu PADs developed using this method showed excellent precision for determination of trace concentrations of aluminium (average RSDs = 3.38% and 6.45%, and LODs = 0.5 ng (0.25 ppm) and 2 ng (0.5 ppm), for traditional and distance-based detection, respectively).

Keywords

Microfluidic paper-based analytical device; Reagent deposition; Technical pen; Plotter; Distance-based detection; Aluminium determination

Authors

RAHBAR, M.; NESTERENKO, P.; PAULL, B.; MACKA, M.

Released

24. 1. 2019

Publisher

Elsevier

ISBN

0003-2670

Periodical

ANALYTICA CHIMICA ACTA

Year of study

1047

Number

1

State

Kingdom of the Netherlands

Pages from

115

Pages to

123

Pages count

9

URL

https://www.sciencedirect.com/science/article/pii/S000326701831064X

Full text in the Digital Library

http://hdl.handle.net/11012/138386

BibTex

@article{BUT156231,
  author="Mohammad {Rahbar} and Pavel {Nesterenko} and Brett {Paull} and Miroslav {Macka}",
  title="High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices",
  journal="ANALYTICA CHIMICA ACTA",
  year="2019",
  volume="1047",
  number="1",
  pages="115--123",
  doi="10.1016/j.aca.2018.09.006",
  issn="0003-2670",
  url="https://www.sciencedirect.com/science/article/pii/S000326701831064X"
}