Publication detail

Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona

TESAŘOVÁ, B. DOSTÁLOVÁ, S. CHAROUSOVÁ, M. ŠKUBALOVÁ, Z. GURÁŇ, R. DO, T. ADAM, V. HEGER, Z.

Original Title

Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona

Type

conference paper

Language

English

Original Abstract

The effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin (FRT) were tested in this work. The main goals of performed PEGylation/PASylation were decreased protein corona formation leading to better internalization of drugs into diseased cells and therefore higher efficiency of treatment. The influence of created protein coronas on the amount of internalized experimental drug ellipticine (Elli) was evaluated via fluorescence microscopy. Various properties of these modified nanoparticles were studied, such as their cytotoxicity or release kinetics of Elli. According to performed experiments, PAS-10 modification appeared as the most appropriate surface modification.

Keywords

apoferritin; nanomedicine; PASylation; PEGylation; protein coronas

Authors

TESAŘOVÁ, B.; DOSTÁLOVÁ, S.; CHAROUSOVÁ, M.; ŠKUBALOVÁ, Z.; GURÁŇ, R.; DO, T.; ADAM, V.; HEGER, Z.

Released

2. 1. 2019

Publisher

Mendel University in Brno

ISBN

978-80-7509-597-8

Book

MendelNet 2018

Pages from

542

Pages to

547

Pages count

6

URL

https://mendelnet.cz/artkey/mnt-201801-0115_Effect-of-apoferritin-surface-biomacromolecular-modification-on-cellular-uptake-and-inhibition-of-protein-coron.php?back=/magno/mnt/2018/mn1.php?secid=4

Full text in the Digital Library

http://hdl.handle.net/11012/178389

BibTex

@inproceedings{BUT156247,
  author="Barbora {Tesařová} and Simona {Dostálová} and Markéta {Charousová} and Zuzana {Škubalová} and Roman {Guráň} and Tomáš {Do} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona",
  booktitle="MendelNet 2018",
  year="2019",
  pages="542--547",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-597-8",
  url="https://mendelnet.cz/artkey/mnt-201801-0115_Effect-of-apoferritin-surface-biomacromolecular-modification-on-cellular-uptake-and-inhibition-of-protein-coron.php?back=/magno/mnt/2018/mn1.php?secid=4"
}