Publication detail

Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

REBENDA, D. ČÍPEK, P. VRBKA, M. KŘUPKA, I.

Original Title

Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

Type

conference paper

Language

English

Original Abstract

Hyaluronic acid (HA) is among others one of the component of synovial fluid (SF) and is the main component which affects the rheology of SF. However, during various degenerative joint diseases like osteoarthritis, the concentration and molecular weight of HA in SF is decreasing. In recent times, injections with exogenous HA are gaining popularity as a one of the methods for non-invasive treatment of osteoarthritis. Exogenous HA should improve rheological properties of osteoarthritic SF and has also many physiological effects. One of the key parameters which affects the rheology of HA and the efficiency of viscosupplementation is the molecular weight of HA. In this study, the changes in coefficient of friction between intact porcine cartilage and glass plate during reciprocating sliding tests were analyzed to understand how the changes in molecular weight of HA affects the friction of articular cartilage model. The changes in friction between osteoarthritic SF and mixtures of SF and HA with different molecular weight were also analyzed to assess the significance of exogenous HA molecular weight on cartilage friction after viscosupplementation.

Keywords

hyaluronic acid, friction, biotribology, synovial fluid, viscosupplementation

Authors

REBENDA, D.; ČÍPEK, P.; VRBKA, M.; KŘUPKA, I.

Released

15. 5. 2019

Publisher

University of Kragujevac, Faculty of Engineering

Location

Kragujevac

ISBN

2620-2832

Periodical

Proceedings on Engineering Sciences - 16th International Conference on Tribology

Year of study

1

Number

1

State

Republic of Serbia

Pages from

693

Pages to

697

Pages count

5

BibTex

@inproceedings{BUT157206,
  author="David {Rebenda} and Pavel {Čípek} and Martin {Vrbka} and Ivan {Křupka}",
  title="Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage",
  booktitle="Proceedings on Engineering Sciences - 16th International Conference on Tribology",
  year="2019",
  journal="Proceedings on Engineering Sciences - 16th International Conference on Tribology",
  volume="1",
  number="1",
  pages="693--697",
  publisher="University of Kragujevac, Faculty of Engineering",
  address="Kragujevac",
  issn="2620-2832"
}