Publication detail

Drug Release Kinetics of Electrospun PHB Meshes

KUNDRÁT, V. ČERNEKOVÁ, N. KOVALČÍK, A. ENEV, V. MÁROVÁ, I.

Original Title

Drug Release Kinetics of Electrospun PHB Meshes

Type

journal article in Web of Science

Language

English

Original Abstract

Microbial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model drug for incorporation into PHB electrospun meshes. The entrapment efficiency was found to be dependent on the viscosity of the PHB solution used for electrospinning and ranged from 14.4–81.8%. The incorporation of levofloxacin in electrospun meshes was confirmed by Fourier-transform infrared spectroscopy and UV-VIS spectroscopy. The effect of the morphology of the electrospun meshes on the levofloxacin release profile was screened in vitro in phosphate-buffered saline solution. Depending upon the morphology, the electrospun meshes released about 14–20% of levofloxacin during the first 24 h. The percentage of drug released after 13 days increased up to 32.4% and was similar for all tested morphologies. The antimicrobial efficiency of all tested samples independent of the morphology, was confirmed by agar diffusion testing.

Keywords

biomaterials; electrospinning; drug release kinetics; levofloxacin; morphology; poly(3-hydroxybutyrate); scaffolds

Authors

KUNDRÁT, V.; ČERNEKOVÁ, N.; KOVALČÍK, A.; ENEV, V.; MÁROVÁ, I.

Released

14. 6. 2019

Publisher

MDPI

ISBN

1996-1944

Periodical

Materials

Year of study

12

Number

12

State

Swiss Confederation

Pages from

1

Pages to

13

Pages count

13

URL

https://www.mdpi.com/1996-1944/12/12/1924

Full text in the Digital Library

http://hdl.handle.net/11012/181097

BibTex

@article{BUT157318,
  author="Vojtěch {Kundrát} and Nicole {Černeková} and Adriána {Kovalčík} and Vojtěch {Enev} and Ivana {Márová}",
  title="Drug Release Kinetics of Electrospun PHB Meshes",
  journal="Materials",
  year="2019",
  volume="12",
  number="12",
  pages="1--13",
  doi="10.3390/ma12121924",
  issn="1996-1944",
  url="https://www.mdpi.com/1996-1944/12/12/1924"
}

Documents

materials-12-01924.pdf