Publication detail

p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system

PORUBIAKOVÁ, O. BRÁZDA, V. BOHÁLOVÁ, N.

Original Title

p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system

Type

abstract

Language

English

Original Abstract

Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.

Keywords

p53alpha isoforms, yeast isogenic system, cruciforms

Authors

PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.

Released

7. 5. 2019

BibTex

@misc{BUT157762,
  author="Otília {Porubiaková} and Václav {Brázda} and Natália {Bohálová}",
  title="p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system",
  year="2019",
  note="abstract"
}