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BRÁZDA, V. JAGELSKÁ, E. B. KOLOMAZNÍK, J. LÝSEK, J. KAURA, P. BARTAS, M. COUFAL, J. ŠŤASTNÝ, J.
Original Title
DNA analyser, a new powerful tool to identify and analyse local DNA structures in genomes
Type
abstract
Language
English
Original Abstract
Local DNA structures play important roles in the regulation of basic biological processes. Whilst computational approaches to identify these structures are available, the number of easily accessible and userfriendly tools is limited, especially for analysis of different types of local structures within long nucleotide sequences. We have developed a webbased server, DNA analyser, which is a userfriendly application for analysing local DNA structures. At first we implemented a tool for analyses of inverted repeats in various nucleic acids sequences including genome sequences and oligonucleotides. It allows users to search and retrieve desired gene/nucleotide sequence entries from the NCBI databases, and provides data on length, sequence, locations and energy required for cruciform formation. We have recently included new tools for analyses of quadruplexforming sequences – an interactive webversion of the G4hunter algorithm as well as a tool to search for p53 target sequences. DNA analyser also features an interactive graphical representation of the distribution of local DNA structures and options for sorting and data export. DNA analyser allows whole genome analyses and it is freely available at http://bioinformatics.ibp.cz
Keywords
DNA analyser, DNA structures, G4hunter algorithm
Authors
BRÁZDA, V.; JAGELSKÁ, E. B.; KOLOMAZNÍK, J.; LÝSEK, J.; KAURA, P.; BARTAS, M.; COUFAL, J.; ŠŤASTNÝ, J.
Released
6. 7. 2019
ISBN
2211-5463
Periodical
FEBS Open Bio
Year of study
9
Number
S1
State
United Kingdom of Great Britain and Northern Ireland
Pages from
149
Pages to
Pages count
1
URL
https://febs.onlinelibrary.wiley.com/toc/22115463/2019/9/S1
BibTex
@misc{BUT157848, author="BRÁZDA, V. and JAGELSKÁ, E. B. and KOLOMAZNÍK, J. and LÝSEK, J. and KAURA, P. and BARTAS, M. and COUFAL, J. and ŠŤASTNÝ, J.", title="DNA analyser, a new powerful tool to identify and analyse local DNA structures in genomes", year="2019", journal="FEBS Open Bio", volume="9", number="S1", pages="149--149", doi="10.1002/2211-5463.12675", issn="2211-5463", url="https://febs.onlinelibrary.wiley.com/toc/22115463/2019/9/S1", note="abstract" }