Publication detail

Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

ČUTOVÁ, M. MANTA, J. PORUBIAKOVÁ, O. KAURA, P. ŠŤASTNÝ, J. BRÁZDOVÁ JÁGELSKÁ, E. GOSWAMI, P. BARTAS, M. BRÁZDA, V.

Original Title

Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Type

journal article in Web of Science

Language

English

Original Abstract

The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes.

Keywords

Inverted repeat; G-quadruplex; Saccharomyces cerevisiae

Authors

ČUTOVÁ, M.; MANTA, J.; PORUBIAKOVÁ, O.; KAURA, P.; ŠŤASTNÝ, J.; BRÁZDOVÁ JÁGELSKÁ, E.; GOSWAMI, P.; BARTAS, M.; BRÁZDA, V.

Released

15. 2. 2020

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE

Location

SAN DIEGO

ISBN

0888-7543

Periodical

GENOMICS

Year of study

112

Number

2

State

United States of America

Pages from

1897

Pages to

1901

Pages count

5

URL

http://www.sciencedirect.com/science/article/pii/S08887543319305269?dgcid=author

BibTex

@article{BUT158717,
  author="Michaela {Čutová} and Jacinta {Manta} and Otília {Porubiaková} and Patrik {Kaura} and Jiří {Šťastný} and Eva {Brázdová Jágelská} and Pratik {Goswami} and Martin {Bartas} and Václav {Brázda}",
  title="Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae",
  journal="GENOMICS",
  year="2020",
  volume="112",
  number="2",
  pages="1897--1901",
  doi="10.1016/j.ygeno.2019.11.002",
  issn="0888-7543",
  url="http://www.sciencedirect.com/science/article/pii/S08887543319305269?dgcid=author"
}