Publication result detail

Collagen-phosphate porous scaffolds for novel bone tissue engineering concept

BRTNÍKOVÁ, J.; PAVLIŇÁKOVÁ, V.; ŠŤASTNÝ, P.; TRUNEC, M.; POLÁČEK, P.; BLAHNOVÁ, V.; FILOVA, E.; VOJTOVÁ, L.

Original Title

Collagen-phosphate porous scaffolds for novel bone tissue engineering concept

English Title

Collagen-phosphate porous scaffolds for novel bone tissue engineering concept

Type

Abstract

Original Abstract

In this work, the bovine collagen type I was combined with calcium phosphates differing in solubility and resorbability. The effect of bioceramics solubility and particle sizes on scaffolds morphology, biomechanics, physical and biological properties was observed. Addition of bioceramic particles changed morphology of the samples resulting in decreasing the pore size, while the porosity becomes nearly the same in all tested samples. The biomechanical properties of the samples were tested in both dry and hydrated state. In dry state, collagen scaffolds reached the highest compressive strength, in contrary to the hydrated state, where samples containing bioceramic particles were stiffer but the strength values were one order lower comparing to samples in dry state. During in-vitro experiments, none of samples was found to be cytotoxic.

English abstract

In this work, the bovine collagen type I was combined with calcium phosphates differing in solubility and resorbability. The effect of bioceramics solubility and particle sizes on scaffolds morphology, biomechanics, physical and biological properties was observed. Addition of bioceramic particles changed morphology of the samples resulting in decreasing the pore size, while the porosity becomes nearly the same in all tested samples. The biomechanical properties of the samples were tested in both dry and hydrated state. In dry state, collagen scaffolds reached the highest compressive strength, in contrary to the hydrated state, where samples containing bioceramic particles were stiffer but the strength values were one order lower comparing to samples in dry state. During in-vitro experiments, none of samples was found to be cytotoxic.

Keywords

collagen scaffold, hydroxyapatite, α- and β-tricalcium phosphate

Key words in English

collagen scaffold, hydroxyapatite, α- and β-tricalcium phosphate

Authors

BRTNÍKOVÁ, J.; PAVLIŇÁKOVÁ, V.; ŠŤASTNÝ, P.; TRUNEC, M.; POLÁČEK, P.; BLAHNOVÁ, V.; FILOVA, E.; VOJTOVÁ, L.

Released

03.12.2018

Publisher

iMedPub LTD

Location

London, UK

ISBN

2394-9988

Periodical

International Journal of Applied Science-Research and Review

Volume

C2

Number

5

State

United Kingdom of Great Britain and Northern Ireland

Pages from

29

Pages to

29

Pages count

74

BibTex

@misc{BUT159489,
  author="Jana {Brtníková} and Veronika {Pavliňáková} and Přemysl {Šťastný} and Martin {Trunec} and Petr {Poláček} and Veronika {Blahnová} and Eva {Filova} and Lucy {Vojtová}",
  title="Collagen-phosphate porous scaffolds for novel bone tissue engineering concept",
  year="2018",
  journal="International Journal of Applied Science-Research and Review",
  volume="C2",
  number="5",
  pages="29--29",
  publisher="iMedPub LTD",
  address="London, UK",
  doi="10.21767/2394-9988-C2-006",
  issn="2394-9988",
  note="Abstract"
}