Publication detail

Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

PERMYAKOVA, E. ANTIPINA, L. KIRYUKHANTSEV-KORNEEV, P. KOVALSKII, A. POLČÁK, J. MANAKHOV, A. GUDZ, K. SOROKIN, P. SHTANSKY, D.

Original Title

Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

Type

journal article in Web of Science

Language

English

Original Abstract

A new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPs(PT)) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPs(PT) were activated by N,N'-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPs(PT) by a chemical reaction between amino groups of EDA-BNNPs(PT) and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPs(PT). It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPs(PT) nanohybrids are preserved.

Keywords

BN nanoparticles; chemical vapor deposition; plasma surface polymerization; folic acid conjugates; drug delivery nanocarriers; density functional theory

Authors

PERMYAKOVA, E.; ANTIPINA, L.; KIRYUKHANTSEV-KORNEEV, P.; KOVALSKII, A.; POLČÁK, J.; MANAKHOV, A.; GUDZ, K.; SOROKIN, P.; SHTANSKY, D.

Released

1. 12. 2019

Publisher

MDPI

Location

BASEL

ISBN

2079-4991

Periodical

Nanomaterials

Year of study

9

Number

12

State

Swiss Confederation

Pages from

1

Pages to

14

Pages count

14

URL

https://www.mdpi.com/2079-4991/9/12/1658

Full text in the Digital Library

http://hdl.handle.net/11012/184682

BibTex

@article{BUT162084,
  author="Elizaveta {Permyakova} and Liubov Yu. {Antipina} and Philip {Kiryukhantsev-Korneev} and Andrey {Kovalskii} and Josef {Polčák} and Anton {Manakhov} and Kristina Yu. {Gudz} and Pavel B. {Sorokin} and Dmitry V. {Shtansky}",
  title="Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study",
  journal="Nanomaterials",
  year="2019",
  volume="9",
  number="12",
  pages="1--14",
  doi="10.3390/nano9121658",
  issn="2079-4991",
  url="https://www.mdpi.com/2079-4991/9/12/1658"
}