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HOOVÁ, J. VYSOKÁ, M. DZURICKÁ, L. MATOUŠKOVÁ, P. MÁROVÁ, I.
Original Title
THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE
Type
conference paper
Language
English
Original Abstract
Extracts from naturally occurred sources, such as plants or microorganisms, have been recently tested for their interesting properties that can be used in food or cosmetic industry. The aim of this work is to encapsulate microbial compounds, some plant extracts and also model hydrophilic and hydrophobic substances. Chosen components were encapsulated into liposomes. Particle size and distributions of liposomes were analyzed by dynamic light scattering and their stability by using zeta potential. Spectrophotometric methods were used to measure encapsulation efficiency and to characterize the chosen plant extracts by its amount of total polyphenols, flavonoids and antioxidant activity. Chosen samples were analyzed for their antimicrobial activity and cytotoxicity. Serratia marcescens, Escherichia coli as gram-negative bacterias, Micrococcus luteus as gram-positive bacteria and fungal strain (Candida glabrata) were used to test antimicrobial activity. Human keratinocytes and mouse melanoma cells were used to cytotoxicity determination. It has been proved that encapsulation techniques help slowly release the active compounds from plant extracts and transport them to targeted location. Antimicrobial effect was also seen before and after encapsulation into liposomes. Moreover, none of the extracts showed evidence of cytotoxicity.
Keywords
Encapsulation; liposomes; polyphenols; antioxidant activity; antimicrobial activity; cytotoxicity
Authors
HOOVÁ, J.; VYSOKÁ, M.; DZURICKÁ, L.; MATOUŠKOVÁ, P.; MÁROVÁ, I.
Released
1. 1. 2019
Publisher
TANGER
Location
Ostrava, Czech republic
ISBN
978-80-87294-89-5
Book
NANOCON 2018, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION
Pages from
386
Pages to
391
Pages count
6
BibTex
@inproceedings{BUT163450, author="Julie {Hoová} and Marie {Vysoká} and Lucia {Dzurická} and Petra {Skoumalová} and Ivana {Márová}", title="THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE", booktitle="NANOCON 2018, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION ", year="2019", pages="386--391", publisher="TANGER", address="Ostrava, Czech republic", isbn="978-80-87294-89-5" }