Publication detail

Novel unexpected functions of PHA granules

OBRUČA, S. SEDLÁČEK, P. SLANINOVÁ, E. FRITZ, I. DAFFERT, C. MEIXNER, K. ŠEDRLOVÁ, Z. KOLLER, M.

Original Title

Novel unexpected functions of PHA granules

Type

journal article in Web of Science

Language

English

Original Abstract

Polyhydroxyalkanoates (PHA), polyesters accumulated by numerous prokaryotes in the form of intracellular granules, have been for decades considered being predominantly storage molecules. However, numerous recent discoveries revealed and emphasized their complex biological role for microbial cells. Most of all, it was repeatedly reported and confirmed that the presence of PHA granules in prokaryotic cells enhances stress resistance and robustness of microbes against various environmental stress factors such as high or low temperature, freezing, oxidative, and osmotic pressure. It seems that protective mechanisms of PHA granules are associated with their extraordinary architecture and biophysical properties as well as with the complex and deeply interconnected nature of PHA metabolism. Therefore, this review aims at describing novel and unexpected properties of PHA granules with respect to their contribution to stress tolerance of various prokaryotes including common mesophilic heterotrophic bacteria, but also extremophiles or photo-autotrophic cyanobacteria.

Keywords

Bacteria; Polyhydroxyalkanoates; PHA granules; Stress robustness; Cupriavidus necator; Extremophiles; Cyanobacteria

Authors

OBRUČA, S.; SEDLÁČEK, P.; SLANINOVÁ, E.; FRITZ, I.; DAFFERT, C.; MEIXNER, K.; ŠEDRLOVÁ, Z.; KOLLER, M.

Released

1. 6. 2020

Publisher

Springer

ISBN

0175-7598

Periodical

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Year of study

104

Number

11

State

Federal Republic of Germany

Pages from

4795

Pages to

4810

Pages count

16

URL

https://link.springer.com/article/10.1007/s00253-020-10568-1

BibTex

@article{BUT164177,
  author="OBRUČA, S. and SEDLÁČEK, P. and SLANINOVÁ, E. and FRITZ, I. and DAFFERT, C. and MEIXNER, K. and ŠEDRLOVÁ, Z. and KOLLER, M.",
  title="Novel unexpected functions of PHA granules",
  journal="APPLIED MICROBIOLOGY AND BIOTECHNOLOGY",
  year="2020",
  volume="104",
  number="11",
  pages="4795--4810",
  doi="10.1007/s00253-020-10568-1",
  issn="0175-7598",
  url="https://link.springer.com/article/10.1007/s00253-020-10568-1"
}