Publication detail

Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)

KOVALČÍK, A. SANGRONIZ, L. KALINA, M. SKOPALOVA, K. HUMPOLÍČEK, P. OMASTOVÁ, M. MUNDIGLER, N. MÜLLER, A.

Original Title

Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)

Type

journal article in Web of Science

Language

English

Original Abstract

Poly(hydroxyalkanoates) are biodegradable and biocompatible polymers suitable for tissue engineering. Fused depositon modeling (FDM) belongs to modern rapid prototyping techniques for the fabrication of scaffolds. In this work, poly(3-hydroxybutyrate (PHB), poly(3-hydroxzbutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate (PHBH) were tested for FDM. Thermal and rheological properties of industrial PHAs were compared with poly(lactic acid) (PLA), which is a biodegradable polymer commonly used for FDM. The massive decrease in viscosity and loss of molecular weight of PHB and PHBV precluded their use for FDM. On the other hand, the thermal stability of PHBH was comparable to that of PLA. PHBH scaffolds prepared by FDM exhibited excellent mechanical properties, no cytotoxicity, and large proliferation of mouse embryonic fibroblast cells within 96 h. The hydrolytic degradation of PHBH and PLA scaffolds tested in synthetic gastric juice for 52 days confirmed a faster degradation of PHBH than PLA. The decrease in molecular weight confirmed the first-order kinetics with a slightly higher (0.0169 day-1) degradation rate constant for pHBH as compared to the value (0.0107 day-1) obtainined for PLA. These results indicate that PHBH could be used to produce scaffolds by FDM with application in tissue engineering.

Keywords

Biodegradation; Cytocompatibility; Mechanical properties; Poly(hydroxyalkanoates);Poly(lactic acid);3D printing

Authors

KOVALČÍK, A.; SANGRONIZ, L.; KALINA, M.; SKOPALOVA, K.; HUMPOLÍČEK, P.; OMASTOVÁ, M.; MUNDIGLER, N.; MÜLLER, A.

Released

15. 10. 2020

Publisher

Elsevier

Location

Amsterdam

ISBN

0141-8130

Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Year of study

161

Number

1

State

Kingdom of the Netherlands

Pages from

364

Pages to

376

Pages count

13

URL

https://www.sciencedirect.com/science/article/pii/S0141813020334590

Full text in the Digital Library

http://hdl.handle.net/11012/195639

BibTex

@article{BUT164644,
  author="Adriána {Kovalčík} and Leire {Sangroniz} and Michal {Kalina} and Katerina {Skopalova} and Petr {Humpolíček} and Mária {Omastová} and Norbert {Mundigler} and Alejandro J. {Müller}",
  title="Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2020",
  volume="161",
  number="1",
  pages="364--376",
  doi="10.1016/j.ijbiomac.2020.06.022",
  issn="0141-8130",
  url="https://www.sciencedirect.com/science/article/pii/S0141813020334590"
}