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ŠŤASTNÁ, E. ČÁSTKOVÁ, K. RÁHEĽ, J.
Original Title
Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers
Type
journal article in Web of Science
Language
English
Original Abstract
Nanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.
Keywords
electrospinning; nanofibers; polycaprolactone; hydroxyapatite; tissue engineering; atmospheric pressure argon plasma
Authors
ŠŤASTNÁ, E.; ČÁSTKOVÁ, K.; RÁHEĽ, J.
Released
20. 8. 2020
Publisher
MDPI
Location
Basel, Švýcarská konfederace
ISBN
2073-4360
Periodical
Polymers
Year of study
12
Number
9
State
Swiss Confederation
Pages from
1
Pages to
16
Pages count
URL
https://www.mdpi.com/2073-4360/12/9/1877
Full text in the Digital Library
http://hdl.handle.net/11012/194808
BibTex
@article{BUT164786, author="Eva {Šťastná} and Klára {Částková} and Jozef {Ráheĺ}", title="Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers", journal="Polymers", year="2020", volume="12", number="9", pages="1--16", doi="10.3390/polym12091877", issn="2073-4360", url="https://www.mdpi.com/2073-4360/12/9/1877" }