Publication detail

Hyaluronan-Arginine Interactions-An Ultrasound and ITC Study

JUGL, A. PEKAŘ, M.

Original Title

Hyaluronan-Arginine Interactions-An Ultrasound and ITC Study

Type

journal article in Web of Science

Language

English

Original Abstract

High-resolution ultrasound spectroscopy and isothermal titration calorimetry were used to characterize interactions between hyaluronan and arginine oligomers. The molecular weight of arginine oligomer plays an important role in interactions with hyaluronan. Interactions were observable for arginine oligomers with eight monomer units and longer chains. The effect of the ionic strength and molecular weight of hyaluronan on interactions was tested. In an environment with increased ionic strength, the length of the arginine oligomer was crucial. Generally, sufficiently high ionic strength suppresses interactions between hyaluronan and arginine oligomers, which demonstrated interactions in water. From the point of view of the molecular weight of hyaluronan, the transition between the rod conformation and the random coil conformation appeared to be important.

Keywords

hyaluronan; arginine; interaction; high-resolution ultrasound spectroscopy; isothermal titration calorimetry

Authors

JUGL, A.; PEKAŘ, M.

Released

12. 9. 2020

Publisher

MDPI

Location

BASEL

ISBN

2073-4360

Periodical

Polymers

Year of study

12

Number

9

State

Swiss Confederation

Pages from

1

Pages to

20

Pages count

20

URL

https://www.mdpi.com/2073-4360/12/9/2069

Full text in the Digital Library

http://hdl.handle.net/11012/195577

BibTex

@article{BUT165162,
  author="Adam {Jugl} and Miloslav {Pekař}",
  title="Hyaluronan-Arginine Interactions-An Ultrasound and ITC Study",
  journal="Polymers",
  year="2020",
  volume="12",
  number="9",
  pages="1--20",
  doi="10.3390/polym12092069",
  issn="2073-4360",
  url="https://www.mdpi.com/2073-4360/12/9/2069"
}