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Publication detail
Zhu, HL. Zhang, HQ. Ni, S. Korabecna, M. Yobas, L. Neuzil, P.
Original Title
The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond
Type
journal article in Web of Science
Language
English
Original Abstract
Infectious diseases, such as the most recent case of coronavirus disease 2019, have brought the prospect of point-of-care (POC) diagnostic tests into the spotlight. A rapid, accurate, low-cost, and easy-to-use test in the field could stop epidemics before they develop into full-blown pandemics. Unfortunately, despite all the advances, it still does not exist. Here, we critically review the limited number of prototypes demonstrated to date that is based on a polymerase chain reaction (PCR) and has come close to fulfill this vision. We summarize the requirements for the POC PCR tests and then go on to discuss the PCR product-detection methods, the integration of their functional components, the potential applications, and other practical issues related to the implementation of lab-on-a-chip technologies. We conclude our review with a discussion of the latest findings on nucleic acid-based diagnosis. (C) 2020 Elsevier B.V. All rights reserved.
Keywords
COVID-19 diagnoses; Polymerase chain reaction; Microfluidics; Miniaturization; Point of care; Future of PCR
Authors
Zhu, HL.; Zhang, HQ.; Ni, S.; Korabecna, M.; Yobas, L.; Neuzil, P.
Released
1. 9. 2020
Publisher
ELSEVIER SCI LTD
Location
OXFORD
ISBN
0165-9936
Periodical
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Year of study
130
Number
115984
State
United Kingdom of Great Britain and Northern Ireland
Pages from
Pages to
Pages count
13
URL
https://www.sciencedirect.com/science/article/pii/S0165993620302132?casa_token=Z2ZbtTb1LWcAAAAA:u6pRqpDLw8a4YLRIgJDrxE5ECMwLBKGAYLVU_7xizQgoBIyT8yQWdit6se91jm0vDmQz9Cz97A
BibTex
@article{BUT165708, author="Zhu, HL. and Zhang, HQ. and Ni, S. and Korabecna, M. and Yobas, L. and Neuzil, P.", title="The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond", journal="TRAC-TRENDS IN ANALYTICAL CHEMISTRY", year="2020", volume="130", number="115984", pages="115984--115984", doi="10.1016/j.trac.2020.115984", issn="0165-9936", url="https://www.sciencedirect.com/science/article/pii/S0165993620302132?casa_token=Z2ZbtTb1LWcAAAAA:u6pRqpDLw8a4YLRIgJDrxE5ECMwLBKGAYLVU_7xizQgoBIyT8yQWdit6se91jm0vDmQz9Cz97A" }