Publication detail

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

POLZER, S. POLIŠENSKÁ, A. NOVÁK, K. BURŠA, J.

Original Title

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

Type

journal article in Web of Science

Language

English

Original Abstract

Peak stress in the fibrous cap of atherosclerotic plaque is largely determined by the cap thickness which cannot be accurately estimated in vivo. This parametric study investigates idealized atherosclerotic plaque geometries. Finite element modeling is applied to search for larger morphological features associated with high cap stresses. By varying seven geometrical and two loading parameters, 100 3D model geometries of atherosclerotic plaques in common iliac artery were generated. In each model peak cap stress was cal- culated, and statistical comparison of the geometries generating the highest and lowest peak cap stresses was performed. The analysis showed that, compared to geometries generating the lowest stresses, those with high peak cap stress had a significantly lower cap thickness, higher stenosis ratio, lower relative lipid core volume, and cap shoulder radius larger than lipid core radius. High cap stress was observed for cap thicknesses up to 0.13 mm. It can be concluded that vulnerable plaques contain thin fibrous cap, large stenosis ratio and only moderate small-radius lipid core which reaches the shoulder region of the fibrous cap. (C) 2019 IPEM. Published by Elsevier Ltd. All rights reserved.

Keywords

Atherosclerotic plaque, Finite element analysis, Parametric study

Authors

POLZER, S.; POLIŠENSKÁ, A.; NOVÁK, K.; BURŠA, J.

Released

29. 7. 2019

Publisher

Elsevier

ISBN

1350-4533

Periodical

MEDICAL ENGINEERING & PHYSICS

Year of study

69

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

140

Pages to

146

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub

BibTex

@article{BUT165765,
  author="Stanislav {Polzer} and Anna {Polišenská} and Kamil {Novák} and Jiří {Burša}",
  title="Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study",
  journal="MEDICAL ENGINEERING & PHYSICS",
  year="2019",
  volume="69",
  number="7",
  pages="140--146",
  doi="10.1016/j.medengphy.2019.04.011",
  issn="1350-4533",
  url="https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub"
}