Publication detail

Femoral bone defect healing using two novel biocompatible degradable materials

SRNEC, R. NEČASOVÁ, A. PROKS, P. SKORIC, M. FILIPEJOVÁ, Z. VOJTOVÁ, L. NEČAS, A.

Original Title

Femoral bone defect healing using two novel biocompatible degradable materials

Type

journal article in Web of Science

Language

English

Original Abstract

This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), anda porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%).

Keywords

Pig, biomaterial, scaffold, animal model, composite, phosphate

Authors

SRNEC, R.; NEČASOVÁ, A.; PROKS, P.; SKORIC, M.; FILIPEJOVÁ, Z.; VOJTOVÁ, L.; NEČAS, A.

Released

26. 5. 2020

Publisher

Acta Veterinaria Brno

Location

Brno

ISBN

1801-7576

Periodical

ACTA VETERINARIA BRNO

Year of study

89

Number

2

State

Czech Republic

Pages from

163

Pages to

169

Pages count

7

URL

https://actavet.vfu.cz/89/2/0163/

Full text in the Digital Library

http://hdl.handle.net/11012/196653

BibTex

@article{BUT166347,
  author="Robert {Srnec} and Andrea {Nečasová} and Pavel {Proks} and Misa {Skoric} and Zita {Filipejová} and Lucy {Vojtová} and Alois {Nečas}",
  title="Femoral bone defect healing using two novel biocompatible degradable materials",
  journal="ACTA VETERINARIA BRNO",
  year="2020",
  volume="89",
  number="2",
  pages="163--169",
  doi="10.2754/avb202089020163",
  issn="1801-7576",
  url="https://actavet.vfu.cz/89/2/0163/"
}

Documents

actavet_2020089020163.pdf