Publication detail

The role of hypoxia‐inducible factor 1 in tumor immune evasion

YOU, L. WU, W. WANG, X. FANG, L. ADAM, V. NEPOVIMOVÁ, E. WU, Q. KUČA, K.

Original Title

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Type

journal article in Web of Science

Language

English

Original Abstract

Hypoxia-inducible factor 1 (HIF-1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF-1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion. In innate and adaptive immune systems, malignant tumor cells avoid their recognition and destruction by HIF-1. Tumor immune evasion allows cancer cells to proliferate and metastasize and is associated with immunotherapy failure and chemoresistance. In the hypoxic tumor microenvironment, HIF-1 signaling suppresses the innate and adaptive immune systems to evade immune attack by inducing the expression of immunosuppressive factors and immune checkpoint molecules, including vascular endothelial growth factor, prostaglandin E-2, and programmed death-ligand 1/programmed death-1. Moreover, HIF-1 blocks tumor-associated antigen presentation via major histocompatibility complex class I chain-related/natural killer group 2, member D signaling. Tumor-associated autophagy and the release of tumor-derived exosomes contribute to HIF-1-mediated immune evasion. This review focuses on recent findings on the potential mechanism(s) underlying the effect of hypoxia and HIF-1 signaling on tumor immune evasion in the hypoxic tumor microenvironment. The effects of HIF-1 on immune checkpoint molecules, immunosuppressive molecules, autophagy, and exosomes have been described. Additionally, the potential role of HIF-1 in the regulation of tumor-derived exosomes, as well as the roles of HIF-1 and exosomes in tumor evasion, are discussed. This study will contribute to our understanding of HIF-1-mediated tumor immune evasion, leading to the development of effective HIF-1-targeting drugs and immunotherapies.

Keywords

exosomes; HIF-1; hypoxia; PD-L1; tumor immune evasion

Authors

YOU, L.; WU, W.; WANG, X.; FANG, L.; ADAM, V.; NEPOVIMOVÁ, E.; WU, Q.; KUČA, K.

Released

12. 5. 2021

Publisher

Wiley

ISBN

0198-6325

Periodical

MEDICINAL RESEARCH REVIEWS

Year of study

41

Number

3

State

United States of America

Pages from

1622

Pages to

1643

Pages count

22

URL

https://onlinelibrary.wiley.com/doi/10.1002/med.21771

Full text in the Digital Library

http://hdl.handle.net/11012/208401

BibTex

@article{BUT167779,
  author="Li {You} and Wenda {Wu} and Xu {Wang} and Liurong {Fang} and Vojtěch {Adam} and Eugenie {Nepovimová} and Qinghua {Wu} and Kamil {Kuča}",
  title="The role of hypoxia‐inducible factor 1 in tumor immune evasion",
  journal="MEDICINAL RESEARCH REVIEWS",
  year="2021",
  volume="41",
  number="3",
  pages="1622--1643",
  doi="10.1002/med.21771",
  issn="0198-6325",
  url="https://onlinelibrary.wiley.com/doi/10.1002/med.21771"
}