Publication detail

Electrical Source Imaging in Freely Moving Rats: Evaluation of a 12-Electrode Cortical Electroencephalography System

JIŘÍČEK, S. KOUDELKA, V. LÁČÍK, J. VEJMOLA, Č. KUŘÁTKO, D. WÓJCIK, D. RAIDA, Z. HLINKA, J. PÁLENÍČEK, T.

Original Title

Electrical Source Imaging in Freely Moving Rats: Evaluation of a 12-Electrode Cortical Electroencephalography System

Type

journal article in Web of Science

Language

English

Original Abstract

This work presents and evaluates a 12-electrode intracranial electroencephalography system developed at the National Institute of Mental Health (Klecany, Czech Republic) in terms of an electrical source imaging (ESI) technique in rats. The electrode system was originally designed for translational research purposes. This study demonstrates that it is also possible to use this well-established system for ESI, and estimates its precision, accuracy, and limitations. Furthermore, this paper sets a methodological basis for future implants. Source localization quality is evaluated using three approaches based on surrogate data, physical phantom measurements, and in vivo experiments. The forward model for source localization is obtained from the FieldTrip-SimBio pipeline using the finite-element method. Rat brain tissue extracted from a magnetic resonance imaging template is approximated by a single-compartment homogeneous tetrahedral head model. Four inverse solvers were tested: standardized low-resolution brain electromagnetic tomography, exact low-resolution brain electromagnetic tomography (eLORETA), linear constrained minimum variance (LCMV), and dynamic imaging of coherent sources. Based on surrogate data, this paper evaluates the accuracy and precision of all solvers within the brain volume using error distance and reliability maps. The mean error distance over the whole brain was found to be the lowest in the eLORETA solution through signal to noise ratios (SNRs) (0.2 mm for 25 dB SNR). The LCMV outperformed eLORETA under higher SNR conditions, and exhibiting higher spatial precision. Both of these inverse solvers provided accurate results in a phantom experiment (1.6 mm mean error distance across shallow and 2.6 mm across subcortical testing dipoles). Utilizing the developed technique in freely moving rats, an auditory steady-state response experiment provided results in line with previously reported findings. The obtained results support the idea of utilizing a 12-electrode system for ESI and using it as a solid basis for the development of future ESI dedicated implants.

Keywords

Electroencephalography; preclinical models; electrical source imaging; translational research; auditory steady-state response experiment; fieldtrip

Authors

JIŘÍČEK, S.; KOUDELKA, V.; LÁČÍK, J.; VEJMOLA, Č.; KUŘÁTKO, D.; WÓJCIK, D.; RAIDA, Z.; HLINKA, J.; PÁLENÍČEK, T.

Released

25. 1. 2021

Publisher

Frontiers

Location

Lausanne, Switzerland

ISBN

1662-5196

Periodical

Frontiers in Neuroinformatics

Year of study

14

Number

1

State

Swiss Confederation

Pages from

1

Pages to

22

Pages count

22

URL

https://www.frontiersin.org/articles/10.3389/fninf.2020.589228/full

Full text in the Digital Library

http://hdl.handle.net/11012/196713

BibTex

@article{BUT168939,
  author="Stanislav {Jiříček} and Vlastimil {Koudelka} and Jaroslav {Láčík} and Čestmír {Vejmola} and David {Kuřátko} and Daniel Krzysztof {Wójcik} and Zbyněk {Raida} and Jaroslav {Hlinka} and Tomáš {Páleníček}",
  title="Electrical Source Imaging in Freely Moving Rats: Evaluation of a 12-Electrode Cortical Electroencephalography System",
  journal="Frontiers in Neuroinformatics",
  year="2021",
  volume="14",
  number="1",
  pages="1--22",
  doi="10.3389/fninf.2020.589228",
  issn="1662-5196",
  url="https://www.frontiersin.org/articles/10.3389/fninf.2020.589228/full"
}