Publication detail

Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties

MELČOVÁ, V. CHALOUPKOVÁ, K. VOJTOVÁ, L. RAMPICHOVÁ, M.

Original Title

Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties

Type

abstract

Language

English

Original Abstract

Additive manufacturing or 3D printing is a production technology capable of producing nearly any desired shape including complex porous structures. Thanks to this, it is often exploited for the man-ufacturing of scaffolds for tissue engineering, a modern approach of regenerative medicine. In this work, we have successfully prepared plasticized poly(3-hydroxybutyrate)/polylactide 70/30 blends modified with bioceramic tricalcium phosphate (13 wt%) and used them for Fused Deposition Modeling 3D printing. Two commercial plasticizers, Citroflex B6 (n-Butyryl tri-n-hexyl citrate) and Syncroflex 3114 (oligomeric adipate ester), in the amount of 12 wt% were used. the materials were firstly subjected to print-ing parameters optimization, afterwards printability, thermal and mechanical testing and as well as series of biological tests in vitrowere conducted. Citroflex plasticizer was proven to be effective in enhancing the processability and mechanical properties of stud-ied biopolymer blend, however the biocompatibility of samples with this citrate-based plasticizer was rather poor. on the other hand, Syncroflex materials showed better warping properties than commercial grade PLA filament and moreover the results of bio-logical tests revealed its potential to be used for stem cell-seeded scaffolds for regenerative medicine of bones

Keywords

additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds

Authors

MELČOVÁ, V.; CHALOUPKOVÁ, K.; VOJTOVÁ, L.; RAMPICHOVÁ, M.

Released

27. 11. 2020

Publisher

Vysoké učení technické v Brně, Fakulta chemická

Location

Brno

ISBN

978-80-214-5920-0

Book

Sborník abstraktů Chemie je živo 2020

Edition number

1.

Pages from

106

Pages to

107

Pages count

166

URL

https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641

BibTex

@misc{BUT169253,
  author="MELČOVÁ, V. and CHALOUPKOVÁ, K. and VOJTOVÁ, L. and RAMPICHOVÁ, M.",
  title="Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties",
  booktitle="Sborník abstraktů Chemie je živo 2020",
  year="2020",
  edition="1.",
  pages="106--107",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Brno",
  isbn="978-80-214-5920-0",
  url="https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641",
  note="abstract"
}

Documents

Sbornik-abstrakty-konference-2020.pdf