Publication detail

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

HILŠER, P. SUCHÁNKOVÁ, A. MENDOVÁ, K. FILIPIČ, K.E. DANIEL, M. VRBKA, M.

Original Title

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Type

journal article in Scopus

Language

English

Original Abstract

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.

Keywords

Articular cartilage; Viscosupplement; Hyaluronic acid; Phospholipids; Mica; Hydration lubrication; Friction

Authors

HILŠER, P.; SUCHÁNKOVÁ, A.; MENDOVÁ, K.; FILIPIČ, K.E.; DANIEL, M.; VRBKA, M.

Released

6. 2. 2021

Publisher

Elsevier Ltd

Location

Radarweg 29, 1043 NX Amsterdam, The Netherlands

ISBN

2352-5738

Periodical

Biotribology

Year of study

25

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

100166

Pages to

100166

Pages count

11

URL

https://www.sciencedirect.com/science/article/pii/S235257382100007X

BibTex

@article{BUT169575,
  author="HILŠER, P. and SUCHÁNKOVÁ, A. and MENDOVÁ, K. and FILIPIČ, K.E. and DANIEL, M. and VRBKA, M.",
  title="A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction",
  journal="Biotribology",
  year="2021",
  volume="25",
  number="1",
  pages="100166--100166",
  doi="10.1016/j.biotri.2021.100166",
  issn="2352-5738",
  url="https://www.sciencedirect.com/science/article/pii/S235257382100007X"
}