Publication detail

Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial

BRABENEC, L. KLOBUŠIAKOVÁ, P. ŠIMKO, P. KOŠŤÁLOVÁ, M. MEKYSKA, J. REKTOROVÁ, I.

Original Title

Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial

Type

journal article in Web of Science

Language

English

Original Abstract

Background: Hypokinetic dysarthria is a common but difficult-to-treat symptom of Parkinson’s disease (PD). Objectives: We evaluated the long-term effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Neural mechanisms of stimulation were assessed by functional MRI. Methods: A randomized parallel-group sham stimulation-controlled design was used. Patients were randomly assigned to ten sessions (2 weeks) of real (1 Hz) or sham stimulation over the right superior temporal gyrus. Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Articulation, prosody, and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score of the Dysarthric Profile). Activations of the speech network regions and intrinsic connectivity were assessed using 3T MRI. Linear mixed models and post-hoc tests were utilized for data analyses. Results: Altogether 33 PD patients completed the study (20 in the real stimulation group and 13 in the sham stimulation group). Linear mixed models revealed significant effects of time (F(3, 88.1) = 22.7, p < 0.001) and time-by-group interactions: F(3, 88.0) = 2.8, p = 0.040) for the Phonetics score. Real as compared to sham stimulation led to activation increases in the orofacial sensorimotor cortex and caudate nucleus and to increased intrinsic connectivity of these regions with the stimulated area. Conclusions: This is the first study to show the long-term treatment effects of non-invasive brain stimulation for hypokinetic dysarthria in PD. Neural mechanisms of the changes are discussed.

Keywords

Parkinson’s disease; hypokinetic dysarthria; rTMS; fMRI; dorsal language pathway

Authors

BRABENEC, L.; KLOBUŠIAKOVÁ, P.; ŠIMKO, P.; KOŠŤÁLOVÁ, M.; MEKYSKA, J.; REKTOROVÁ, I.

Released

1. 5. 2021

Publisher

Elsevier

ISBN

1935-861X

Periodical

BRAIN STIMUL

Year of study

14

Number

3

State

United States of America

Pages from

571

Pages to

578

Pages count

8

URL

https://www.sciencedirect.com/science/article/pii/S1935861X21000619

Full text in the Digital Library

http://hdl.handle.net/11012/203212

BibTex

@article{BUT171119,
  author="Luboš {Brabenec} and Patrícia {Klobušiaková} and Patrik {Šimko} and Milena {Košťálová} and Jiří {Mekyska} and Irena {Rektorová}",
  title="Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial",
  journal="BRAIN STIMUL",
  year="2021",
  volume="14",
  number="3",
  pages="571--578",
  doi="10.1016/j.brs.2021.03.010",
  issn="1935-861X",
  url="https://www.sciencedirect.com/science/article/pii/S1935861X21000619"
}