Publication detail

Superparamagnetic electrospun microrods for magnetically-guided pulmonary drug delivery with magnetic heating

NIKOLAOU, M AVRAAM, K KOLOKITHAS-NTOUKAS, A BAKANDRITSOS, A LIZAL, F MISIK, O MALY, M JEDELSKY, J SAVVA, I BALANEAN, F KRASIA-CHRISTOFOROU, T

Original Title

Superparamagnetic electrospun microrods for magnetically-guided pulmonary drug delivery with magnetic heating

Type

journal article in Web of Science

Language

English

Original Abstract

Controlled pulmonary drug delivery systems employing non-spherical particles as drug carriers attract considerable attention nowadays. Such anisotropic morphologies may travel deeper into the lung airways, thus enabling the efficient accumulation of therapeutic compounds at the point of interest and subsequently their sustained release. This study focuses on the fabrication of electrospun superparamagnetic polymer-based biodegradable microrods consisting of poly(L-lactide) (PLLA), polyethylene oxide (PEO) and oleic acid-coated magnetite nanoparticles (OA center dot Fe3O4). The production of magnetite-free (0% wt. OA center dot Fe3O4) and magnetiteloaded (50% and 70% wt. Fe3O4) microrods was realized upon subjecting the as-prepared electrospun fibers to UV irradiation, followed by sonication. Moreover, drug-loaded microrods were fabricated incorporating methyl 4-hydroxybenzoate (MHB) as a model pharmaceutical compound and the drug release profile from both, the drug-loaded membranes and the corresponding microrods was investigated in aqueous media. In addition, the magnetic properties of the produced materials were exploited for remote induction of hyperthermia under AC magnetic field, while the possibility to reduce transport losses and enhance the targeted delivery to lower airways by manipulation of the airborne microrods by DC magnetic field was also demonstrated.

Keywords

Electrospinning; Biodegradable microrods; Pulmonary drug delivery; Superparamagnetic fibers; Magnetic hyperthermia; Magnetic field; Human airways; Lungs

Authors

NIKOLAOU, M; AVRAAM, K; KOLOKITHAS-NTOUKAS, A; BAKANDRITSOS, A; LIZAL, F; MISIK, O; MALY, M; JEDELSKY, J; SAVVA, I; BALANEAN, F; KRASIA-CHRISTOFOROU, T

Released

1. 6. 2021

Publisher

ELSEVIER

Location

AMSTERDAM

ISBN

0928-4931

Periodical

Materials Science and Engineering C-Materials for Biological Applications

Year of study

126

Number

112117

State

Kingdom of the Netherlands

Pages from

1

Pages to

11

Pages count

11

URL

https://www.sciencedirect.com/science/article/pii/S0928493121002563?via%3Dihub

BibTex

@article{BUT171967,
  author="NIKOLAOU, M and AVRAAM, K and KOLOKITHAS-NTOUKAS, A and BAKANDRITSOS, A and LIZAL, F and MISIK, O and MALY, M and JEDELSKY, J and SAVVA, I and BALANEAN, F and KRASIA-CHRISTOFOROU, T",
  title="Superparamagnetic electrospun microrods for magnetically-guided pulmonary drug delivery with magnetic heating",
  journal="Materials Science and Engineering C-Materials for Biological Applications",
  year="2021",
  volume="126",
  number="112117",
  pages="1--11",
  doi="10.1016/j.msec.2021.112117",
  issn="0928-4931",
  url="https://www.sciencedirect.com/science/article/pii/S0928493121002563?via%3Dihub"
}