Publication detail

Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans

HAMZA, A.

Original Title

Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans

Type

journal article in Web of Science

Language

English

Original Abstract

Motor evoked potentials (MEPs) obtained from transcranial magnetic stimulation (TMS) allow corticospinal excitability (CSE) to be measured in the human primary motor cortex (M1). CSE responses to transcranial direct current stimulation (tDCS) protocols are highly variable. Here, we tested the reproducibility and reliability of individual MEPs following a common anodal tDCS protocol. In this study, 32 healthy subjects received anodal tDCS stimulation over the left M1 for three durations (tDCS-T5, tDCS-T10, and tDCS-T20 min) on separate days in a crossover-randomized order. After the resting motor threshold (RMT) was determined for the contralateral first dorsal interosseous muscle, 15 single pulses 4-8 sec apart at an intensity of 120% RMT were delivered to the left M1 to determine the baseline MEP amplitude at T-0, T-5, T-10, T-20, T-30, T-40, T-50, and T-60 min after stimulation for each durations. During TMS delivery, 3D images of the participant's cortex and hot spot were visualized for obtaining MEPs from same position. Our findings revealed that there was a significant MEPs improvement at T-0 (P = 0.01) after 10 min of anodal stimulation. After the 20-min stimulation duration, MEPs differed specifically at T-0,T- T-5,T- T-30 min (P < 0.05). This indicates that tDCS is a promising tool to improve MEPs. Our observed variability in response to the tDCS protocol is consistent with other noninvasive brain stimulation studies.

Keywords

Corticospinal excitability; Motor cortex; Motor evoked potentials; Resting motor threshold; Transcranial direct current stimulation

Authors

HAMZA, A.

Released

2. 4. 2019

Publisher

WILEY

Location

HOBOKEN

ISBN

2051-817X

Periodical

Physiological Reports

Year of study

7

Number

20

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

11

Pages count

11

URL

https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14087

BibTex

@article{BUT172196,
  author="Ali {Hamza}",
  title="Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans",
  journal="Physiological Reports",
  year="2019",
  volume="7",
  number="20",
  pages="1--11",
  doi="10.14814/phy2.14087",
  issn="2051-817X",
  url="https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14087"
}