Publication detail

Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: A longitudinal electroencephalography investigation

DELL, K. PAYNE, D. KŘEMEN, V. MATURANA, M. GERLA, V. NEJEDLÝ, P. WORRELL, G. LHOTSKA, L. MÍVALT, F. BOSTON, R. BRINKMANN, B. WENDYL, D. BURKITT, A. GRAYDEN, D. KUHLMANN, L. FREESTONE, D. COOK, M.

Original Title

Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: A longitudinal electroencephalography investigation

Type

journal article in Web of Science

Language

English

Original Abstract

Background: While the effects of prolonged sleep deprivation (≥24 h) on seizure occurrence has been thoroughly explored, little is known about the effects of day-to-day variations in the duration and quality of sleep on seizure probability. A better understanding of the interaction between sleep and seizures may help to improve seizure management. Methods: To explore how sleep and epileptic seizures are associated, we analysed continuous intracranial electroencephalography (EEG) recordings collected from 10 patients with refractory focal epilepsy undergoing ordinary life activities between 2010 and 2012 from three clinical centres (Austin Health, The Royal Melbourne Hospital, and St Vincent's Hospital of the Melbourne University Epilepsy Group). A total of 4340 days of sleep-wake data were analysed (average 434 days per patient). EEG data were sleep scored using a semi-automated machine learning approach into wake, stages one, two, and three non-rapid eye movement sleep, and rapid eye movement sleep categories. Findings: Seizure probability changes with day-to-day variations in sleep duration. Logistic regression models revealed that an increase in sleep duration, by 1·66 ± 0·52 h, lowered the odds of seizure by 27% in the following 48 h. Following a seizure, patients slept for longer durations and if a seizure occurred during sleep, then sleep quality was also reduced with increased time spent aroused from sleep and reduced rapid eye movement sleep. Interpretation: Our results suggest that day-to-day deviations from regular sleep duration correlates with changes in seizure probability. Sleeping longer, by 1·66 ± 0·52 h, may offer protective effects for patients with refractory focal epilepsy, reducing seizure risk. Furthermore, the occurrence of a seizure may disrupt sleep patterns by elongating sleep and, if the seizure occurs during sleep, reducing its quality.

Keywords

Epilepsy;Seizures;Convulsions;Sleep; Sleep quality; Sleep duration; Sleep composition; Sleep architecture; Rapid eye movement; Long-term; EEG; Electroencephalography; Non-rapid eye movement;

Authors

DELL, K.; PAYNE, D.; KŘEMEN, V.; MATURANA, M.; GERLA, V.; NEJEDLÝ, P.; WORRELL, G.; LHOTSKA, L.; MÍVALT, F.; BOSTON, R.; BRINKMANN, B.; WENDYL, D.; BURKITT, A.; GRAYDEN, D.; KUHLMANN, L.; FREESTONE, D.; COOK, M.

Released

1. 7. 2021

Publisher

The Lancet Publishing Group

ISBN

2589-5370

Periodical

EClinicalMedicine

Year of study

37

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

12

Pages count

12

URL

https://www.sciencedirect.com/science/article/pii/S2589537021002145

Full text in the Digital Library

http://hdl.handle.net/11012/201545

BibTex

@article{BUT172327,
  author="Katrina L. {Dell} and Daniel E. {Payne} and Václav {Křemen} and Matias I. {Maturana} and Václav {Gerla} and Petr {Nejedlý} and Gregory {Worrell} and Lenka {Lhotska} and Filip {Mívalt} and Raymond C. {Boston} and Benjamin H. {Brinkmann} and D'Souza {Wendyl} and Anthony N. {Burkitt} and David B. {Grayden} and Levin {Kuhlmann} and Dean R. {Freestone} and Mark J. {Cook}",
  title="Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: A longitudinal electroencephalography investigation",
  journal="EClinicalMedicine",
  year="2021",
  volume="37",
  number="7",
  pages="1--12",
  doi="10.1016/J.ECLINM.2021.100934",
  issn="2589-5370",
  url="https://www.sciencedirect.com/science/article/pii/S2589537021002145"
}