Publication detail

Group Testing for SARS-CoV-2 Allows for Up to 10-Fold Efficiency Increase Across Realistic Scenarios and Testing Strategies

VERDUN, C.M. FUCHS, T. HARAR, P. ELBRÄCHTER, D. FISCHER, D.S. BERNER, J. GROHS, P. THEIS, F.J. KRAHMER, F.

Original Title

Group Testing for SARS-CoV-2 Allows for Up to 10-Fold Efficiency Increase Across Realistic Scenarios and Testing Strategies

Type

journal article in Web of Science

Language

English

Original Abstract

Background: Due to the ongoing COVID-19 pandemic, demand for diagnostic testing has increased drastically, resulting in shortages of necessary materials to conduct the tests and overwhelming the capacity of testing laboratories. The supply scarcity and capacity limits affect test administration: priority must be given to hospitalized patients and symptomatic individuals, which can prevent the identification of asymptomatic and presymptomatic individuals and hence effective tracking and tracing policies. We describe optimized group testing strategies applicable to SARS-CoV-2 tests in scenarios tailored to the current COVID-19 pandemic and assess significant gains compared to individual testing. Methods: We account for biochemically realistic scenarios in the context of dilution effects on SARS-CoV-2 samples and consider evidence on specificity and sensitivity of PCR-based tests for the novel coronavirus. Because of the current uncertainty and the temporal and spatial changes in the prevalence regime, we provide analysis for several realistic scenarios and propose fast and reliable strategies for massive testing procedures. Key Findings: We find significant efficiency gaps between different group testing strategies in realistic scenarios for SARS-CoV-2 testing, highlighting the need for an informed decision of the pooling protocol depending on estimated prevalence, target specificity, and high- vs. low-risk population. For example, using one of the presented methods, all 1.47 million inhabitants of Munich, Germany, could be tested using only around 141 thousand tests if the infection rate is below 0.4% is assumed. Using 1 million tests, the 6.69 million inhabitants from the city of Rio de Janeiro, Brazil, could be tested as long as the infection rate does not exceed 1%. Moreover, we provide an interactive web application, available at , for visualizing the different strategies and designing pooling schemes according to specific prevalence scenarios and test configurations. Interpretation: Altogether, this work may help provide a basis for an efficient upscaling of current testing procedures, which takes the population heterogeneity into account and is fine-grained towards the desired study populations, e.g., mild/asymptomatic individuals vs. symptomatic ones but also mixtures thereof.

Keywords

group testing; SARS-CoV-2; pooling; COVID-19; informative testing; RT-PCR

Authors

VERDUN, C.M.; FUCHS, T.; HARAR, P.; ELBRÄCHTER, D.; FISCHER, D.S.; BERNER, J.; GROHS, P.; THEIS, F.J.; KRAHMER, F.;

Released

18. 8. 2021

Publisher

Frontiers Media S.A.

Location

Switzerland

ISBN

2296-2565

Periodical

Frontiers in Public Health

Year of study

9

Number

1

State

Swiss Confederation

Pages from

1205

Pages to

1218

Pages count

13

URL

https://www.frontiersin.org/articles/10.3389/fpubh.2021.583377

Full text in the Digital Library

http://hdl.handle.net/11012/204050

BibTex

@article{BUT172366,
  author="Claudio Mayrink {Verdun} and Tim {Fuchs} and Pavol {Harár} and Dennis {Elbraechter} and David {Fischer} and Julius {Berner} and Philipp {Grohs} and Fabian {Theis} and Felix {Krahmer}",
  title="Group Testing for SARS-CoV-2 Allows for Up to 10-Fold Efficiency Increase Across Realistic Scenarios and Testing Strategies",
  journal="Frontiers in Public Health",
  year="2021",
  volume="9",
  number="1",
  pages="1205--1218",
  doi="10.3389/fpubh.2021.583377",
  issn="2296-2565",
  url="https://www.frontiersin.org/articles/10.3389/fpubh.2021.583377"
}