Publication detail

Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting

BISWAS, A. MONDAL, S. KUMAR DAS, S. BOSE, A. THOMAS, S. GHOSAL, K. ROY, S. PROVAZNÍK, I.

Original Title

Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting

Type

journal article in Web of Science

Language

English

Original Abstract

Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.

Keywords

Natural Products, Interpenetrating polymer network, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC).

Authors

BISWAS, A.; MONDAL, S.; KUMAR DAS, S.; BOSE, A.; THOMAS, S.; GHOSAL, K.; ROY, S.; PROVAZNÍK, I.

Released

25. 10. 2021

Publisher

American Chemical Society

Location

New York

ISBN

2470-1343

Periodical

ACS OMEGA

Year of study

6

Number

43

State

United States of America

Pages from

28699

Pages to

28709

Pages count

10

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/

Full text in the Digital Library

http://hdl.handle.net/11012/203079

BibTex

@article{BUT173140,
  author="Avirup {Biswas} and Sancharee {Mondal} and Sanjoy {Kumar Das} and Anindya {Bose} and Sabu {Thomas} and Kajal {Ghosal} and Sudeep {Roy} and Valentine {Provazník}",
  title="Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting",
  journal="ACS OMEGA",
  year="2021",
  volume="6",
  number="43",
  pages="28699--28709",
  doi="10.1021/acsomega.1c03363",
  issn="2470-1343",
  url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/"
}