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ČERNOHLÁVEK, M. BRANDEJSOVÁ, M. ŠTĚPÁN, P. VÁGNEROVÁ, H. HERMANNOVÁ, M. KOPECKÁ, K. KULHÁNEK, J. NEČAS, D. VRBKA, M. VELEBNÝ, V. ANGELES, G.
Original Title
Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery
Type
journal article in Web of Science
Language
English
Original Abstract
Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease. High and low molecular weight HA are currently used in ophthalmology. However, a large portion of the current literature on friction and lubrication addresses articular (joint) cartilage. Therefore, eye drops compositions based on HA and its derivatized forms are extensively characterized providing data on the tribological and mucoadhesive properties. The physiochemical properties are investigated in buffers used commonly in eye drops formulations. The tribological investigation reveals that amphiphilic HA-C12 decreases the friction coefficient. At the same time, the combination of trehalose/HA or HAC12 enhances up to eighty-fold the mucoadhesiveness. Thus, it is predicted a prolonged residence time on the surface of the eye. The incorporation of trehalose enhances the protection of human keratinocytes (HaCaT) cells, as demonstrated in an in-vitro cell-desiccation model. The presence of trehalose increases the friction coefficient. Medium molecular weight HA shows significantly lower friction coefficient than high molecular weight HA. This research represents a first, wide array of features of diverse HA forms for eye drops contributing to increase the knowledge of these preparations. The results here presented also provide valuable information for the design of highly performing HA-formulations addressing specific needs before preclinic.
Keywords
hyaluronan; biotribology; friction; lubrication; eye drops
Authors
ČERNOHLÁVEK, M.; BRANDEJSOVÁ, M.; ŠTĚPÁN, P.; VÁGNEROVÁ, H.; HERMANNOVÁ, M.; KOPECKÁ, K.; KULHÁNEK, J.; NEČAS, D.; VRBKA, M.; VELEBNÝ, V.; ANGELES, G.
Released
30. 9. 2021
Publisher
MDPI
Location
Basilej, Švýcarsko
ISBN
2218-273X
Periodical
Biomolecules
Year of study
11
Number
10
State
Swiss Confederation
Pages from
1431
Pages to
Pages count
15
URL
https://www.mdpi.com/2218-273X/11/10/1431/htm
Full text in the Digital Library
http://hdl.handle.net/11012/203067
BibTex
@article{BUT173155, author="Mikuláš {Černohlávek} and Martina {Brandejsová} and Petr {Štěpán} and Hana {Vágnerová} and Martina {Hermannová} and Kateřina {Kopecká} and Jaromír {Kulhánek} and David {Nečas} and Martin {Vrbka} and Vladimír {Velebný} and Gloria Huerta {Angeles}", title="Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery", journal="Biomolecules", year="2021", volume="11", number="10", pages="1431--1431", doi="10.3390/biom11101431", issn="2218-273X", url="https://www.mdpi.com/2218-273X/11/10/1431/htm" }