Publication detail

BIC-BCI2000: A general-purpose hardware and software platform for chronic intracranial neuromodulation

BELSTEN, A. SCHALK, G. MÍVALT, F. WORRELL, S. KIM, I. MESSINA, S. KAUFMAN, T. STAFF, N. HERMES, D. WORRELL, G. MILLER, K. BRUNNER, P.

Original Title

BIC-BCI2000: A general-purpose hardware and software platform for chronic intracranial neuromodulation

Type

presentation, poster

Language

English

Original Abstract

Neuromodulation using intracranial electrical stimulation is effective in the therapeutic treatment of epilepsy, Parkinson’s, essential tremor, and depression. However, contemporary neuromodulation devices depend on having a fundamental understanding of the beneficial effect of electrical stimulation on the underlying electrophysiological pathology, and thus provide limited benefit in developing therapies for less well-understood neurological disorders and diseases. Our study aimed to overcome this limitation by developing a general-purpose hardware and software platform for neuromodulation research and development based on the CorTec Brain Interchange (BIC) and the BCI2000 general-purpose software platform. The BIC is a fully implantable and inductively powered neuromodulation device intended for human use. It supports recording and stimulation through 32 electrodes. While the BIC supports autonomous operation (i.e., rapid stimulation based on prevalent signal conditions), it also allows for streaming of the recorded signals to external applications to analyze signals and initiate stimulation in real time. These two operation modes facilitate the entire range of scientific and clinical investigation of neuromodulation therapies, ranging from the formulation of the scientific hypothesis, over initial validation of the therapeutic intervention, to the eventual clinical trial. Our study worked towards this goal by developing an integrated BIC-BCI2000 system. We implanted the BIC system in a beagle canine. Two AirRay 16-channel grids were subdurally placed over the left and right sensorimotor cortex via a bilateral craniotomy. Over the 77 days of implantation, we performed electrocorticographic (ECoG) recordings in the behaving and asleep canine using the BCI2000 software. Analysis of the recorded ECoG signals revealed the expected oscillatory activity in the beta band. This initial demonstration of the BIC-BCI2000 system demonstrates the viability of general-purpose hardware and software platforms for neuromodulation research and development.

Keywords

brain computer interface; epilepsy; canine

Authors

BELSTEN, A.; SCHALK, G.; MÍVALT, F.; WORRELL, S.; KIM, I.; MESSINA, S.; KAUFMAN, T.; STAFF, N.; HERMES, D.; WORRELL, G.; MILLER, K.; BRUNNER, P.

Released

8. 11. 2021

Publisher

Society for Neuroscience

Location

Chicago, USA

BibTex

@misc{BUT173197,
  author="Alexander F. {Belsten} and Gerwin {Schalk} and Filip {Mívalt} and Samuel {Worrell} and Inyong {Kim} and Steven {Messina} and Timothy {Kaufman} and Nathan {Staff} and Dora {Hermes} and Gregory {Worrell} and Kai J. {Miller} and Peter {Brunner}",
  title="BIC-BCI2000: A general-purpose hardware and software platform for chronic intracranial neuromodulation",
  year="2021",
  publisher="Society for Neuroscience",
  address="Chicago, USA",
  note="presentation, poster"
}