Publication result detail

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

FOLPRECHT, M.; ČERVINKA, D.; PROCHÁZKA, P.

Original Title

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

English Title

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

Type

WoS Article

Original Abstract

This paper is focused on a design of a high-voltage (HV) generator, which is proposed for a high-frequency irreversible electroporation (H-FIRE). The generator produces bursts of bipolar symmetrical pulses. Most HV sources used for cell electroporation are based on a controlled discharge of a capacitor into a resistive load. This solution is very simple, but it is associated with a certain risk of an uncontrolled discharge of the capacitor. We present a different type of the generator, where a DC-AC inverter with pulse transformer is used and where the mentioned risk is eliminated. Our generator is able to deliver bursts with variable length from 50 to 150 μs and a gap between bursts can be set from 0.5 to 1.5 s. Pulse frequency can be varied from 65 to 470 kHz and the output voltage is controlled in two ranges from 0 to 1.3 kV or from 0 to 2.5 kV. Results are presented with resistive load and with tissue impedance load.

English abstract

This paper is focused on a design of a high-voltage (HV) generator, which is proposed for a high-frequency irreversible electroporation (H-FIRE). The generator produces bursts of bipolar symmetrical pulses. Most HV sources used for cell electroporation are based on a controlled discharge of a capacitor into a resistive load. This solution is very simple, but it is associated with a certain risk of an uncontrolled discharge of the capacitor. We present a different type of the generator, where a DC-AC inverter with pulse transformer is used and where the mentioned risk is eliminated. Our generator is able to deliver bursts with variable length from 50 to 150 μs and a gap between bursts can be set from 0.5 to 1.5 s. Pulse frequency can be varied from 65 to 470 kHz and the output voltage is controlled in two ranges from 0 to 1.3 kV or from 0 to 2.5 kV. Results are presented with resistive load and with tissue impedance load.

Keywords

Cell electroporation; tissue ablation; capacitor bank; DC-AC inverter; DC-DC converter; frequency generator; high voltage; rectangular pulses; pulse transformer.

Key words in English

Cell electroporation; tissue ablation; capacitor bank; DC-AC inverter; DC-DC converter; frequency generator; high voltage; rectangular pulses; pulse transformer.

Authors

FOLPRECHT, M.; ČERVINKA, D.; PROCHÁZKA, P.

RIV year

2022

Released

23.11.2021

Publisher

MDPI

ISBN

2079-9292

Periodical

Electronics (MDPI)

Volume

10

Number

23

State

Swiss Confederation

Pages from

1

Pages to

17

Pages count

17

URL

https://www.mdpi.com/2079-9292/10/23/2898

Full text in the Digital Library

http://hdl.handle.net/11012/203238

BibTex

@article{BUT174971,
  author="Martin {Folprecht} and Dalibor {Červinka} and Petr {Procházka}",
  title="Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)",
  journal="Electronics (MDPI)",
  year="2021",
  volume="10",
  number="23",
  pages="1--17",
  doi="10.3390/electronics10232898",
  issn="2079-9292",
  url="https://www.mdpi.com/2079-9292/10/23/2898"
}

Documents

electronics-10-02898-v2