Publication detail

Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease

BRABENEC, L. ŠIMKO, P. KLOBUŠIAKOVÁ, P. ŠEJNOHA-MINSTEROVÁ, A. KOŠŤÁLOVÁ, M. MEKYSKA, J. REKTOROVÁ, I.

Original Title

Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease

Type

abstract

Language

English

Original Abstract

Background and aims: Hypokinetic dysarthria is a common symptom of Parkinson’s disease (PD) that does not respond well to PD treatments. We examined the longterm effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Methods: A randomized parallel-group sham stimulationcontrolled design was used. Patients were assigned to ten sessions of real (1 Hz) or sham stimulation over the right superior temporal gyrus (STG). Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Prosody, articulation and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score). Activations of the speech network regions, structural and functional connectivity were analyzed. Results: Altogether 33 PD patients completed the study. Linear mixed model showed significant time-by-group interactions for the Phonetics score (p=0.040). Real as compared to sham stimulation led to increased activations of the left orofacial sensorimotor cortex (OFSM1) (p=0.032) and left caudate nucleus (p=0.029) and to increased intrinsic connectivity of the OFSM1 with the stimulated area (p=0.045). A significant positive correlation was found between the temporal evolution of the Phonetics score and the STG-OFSM1 functional connectivity changes in the real stimulation group (r=0.449, p=0.013). DTI analysis revealed that real as compared to sham stimulation significantly increased fractional anisotropy and decreased mean diffusivity in the left anterior arcuate fasciculus (p=0.002; p=0.036). Conclusion: This is the first study to show the long-lasting effects of low-frequency rTMS on hypokinetic dysarthria in PD.

Keywords

Parkinson's disease; hypokinetic dysarthria; transcranial magnetic stimulation

Authors

BRABENEC, L.; ŠIMKO, P.; KLOBUŠIAKOVÁ, P.; ŠEJNOHA-MINSTEROVÁ, A.; KOŠŤÁLOVÁ, M.; MEKYSKA, J.; REKTOROVÁ, I.

Released

1. 6. 2021

ISBN

1351-5101

Periodical

European Journal of Neurology

Year of study

28

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

274

Pages to

274

Pages count

1

URL

https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974

BibTex

@misc{BUT175136,
  author="BRABENEC, L. and ŠIMKO, P. and KLOBUŠIAKOVÁ, P. and ŠEJNOHA-MINSTEROVÁ, A. and KOŠŤÁLOVÁ, M. and MEKYSKA, J. and REKTOROVÁ, I.",
  title="Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease",
  year="2021",
  journal="European Journal of Neurology",
  volume="28",
  number="1",
  pages="274--274",
  issn="1351-5101",
  url="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974",
  note="abstract"
}