Publication detail

Organic electrolytic photocapacitors for stimulation of the mouse somatosensory cortex

MISSEY, F. BOTZANOWSKI, B. MIGLIACCIO, L. ACERBO, E. GLOWACKI, E. WILLIAMSON, A.

Original Title

Organic electrolytic photocapacitors for stimulation of the mouse somatosensory cortex

Type

journal article in Web of Science

Language

English

Original Abstract

Objective. For decades electrical stimulation has been used in neuroscience to investigate brain networks and been deployed clinically as a mode of therapy. Classically, all methods of electrical stimulation require implanted electrodes to be connected in some manner to an apparatus which provides power for the stimulation itself. Approach. We show the use of novel organic electronic devices, specifically organic electrolytic photocapacitors (OEPCs), which can be activated when illuminated with deep-red wavelengths of light and correspondingly do not require connections with external wires or power supplies when implanted at various depths in vivo. Main results. We stimulated cortical brain tissue of mice with devices implanted subcutaneously, as well as beneath both the skin and skull to demonstrate a wireless stimulation of the whisker motor cortex. Devices induced both a behavior response (whisker movement) and a sensory response in the corresponding sensory cortex. Additionally, we showed that coating OEPCs with a thin layer of a conducting polymer formulation (PEDOT:PSS) significantly increases their charge storage capacity, and can be used to further optimize the applied photoelectrical stimulation. Significance. Overall, this new technology can provide an on-demand electrical stimulation by simply using an OEPC and a deep-red wavelength illumination. Wires and interconnects to provide power to implanted neurostimulation electrodes are often problematic in freely-moving animal research and with implanted electrodes for long-term therapy in patients. Our wireless brain stimulation opens new perspectives for wireless electrical stimulation for applications in fundamental neurostimulation and in chronic therapy.

Keywords

wireless brain stimulation; noninvasive brain stimulation; bioelectronics; photovoltaics; cortical stimulation; whisker cortical areas; neuroengineering

Authors

MISSEY, F.; BOTZANOWSKI, B.; MIGLIACCIO, L.; ACERBO, E.; GLOWACKI, E.; WILLIAMSON, A.

Released

1. 12. 2021

Publisher

IOP Publishing

Location

BRISTOL

ISBN

1741-2552

Periodical

Journal of Neural Engineering

Year of study

18

Number

6

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

11

Pages count

11

URL

https://iopscience.iop.org/article/10.1088/1741-2552/ac37a6

Full text in the Digital Library

http://hdl.handle.net/11012/204022

BibTex

@article{BUT176505,
  author="Florian {Missey} and Boris {Botzanowski} and Ludovico {Migliaccio} and Emma {Acerbo} and Eric Daniel {Glowacki} and Adam {Williamson}",
  title="Organic electrolytic photocapacitors for stimulation of the mouse somatosensory cortex",
  journal="Journal of Neural Engineering",
  year="2021",
  volume="18",
  number="6",
  pages="1--11",
  doi="10.1088/1741-2552/ac37a6",
  issn="1741-2552",
  url="https://iopscience.iop.org/article/10.1088/1741-2552/ac37a6"
}